EGFR-TKI-sensitive mutations in lung carcinomas: are they related to clinical features and CT findings?

Abstract

BackgroundEpidermal growth factor receptor (EGFR) mutation testing is restricted to several limitations. In this study, we examined the relationship between EGFR mutation status and clinicoradiological characteristics in a Chinese cohort of patients.Materials and methodsThe data of patients who were diagnosed with lung carcinoma and underwent both EGFR testing and chest computed tomography (CT) at our hospital between January 1, 2011, and November 31, 2015, were retrospectively analyzed. The age, sex, and smoking index of the patients, the size, margin, and density of the tumor, and the presence of specific signs visible on the CT images were assessed.ResultsThe results showed a higher rate of EGFR-tyrosine kinase inhibitor (TKI)-sensitive group than nonsensitive group in female patients and patients with a low smoking index (P<0.001, both). In logistic regression analyses, tumor size (P<0.001), smooth margins (P=0.015), and angular margins (P<0.001) were independent negative predictors of EGFR-TKI-sensitive group. Pleural indentation (P<0.001) and air bronchogram (P=0.025) were independent positive predictors of EGFR-TKI-sensitive group. Patients with squamous cell carcinoma had fewer sensitive mutations than those with either adenocarcinoma (P<0.001) or adenosquamous carcinoma (P<0.001).ConclusionClinical and CT characteristics differed significantly between EGFR-TKI-sensitive and nonsensitive groups. Our findings may be useful in deciding therapeutic strategies for patients in whom EGFR testing is not possible.

Clinical and CT patterns to predict EGFR mutation in patients with non-small cell lung cancer: A systematic literature review and meta-analysis

“…A total of 34 retrospective diagnostic accuracy studies were included in the final analysis [9] , [12] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] . These articles assessed 10355 individuals; the sample size fluctuated between 64 and 864 patients per study.…”

Development and Validation of a Concise Prediction Scoring System for Asian Lung Cancer Patients with EGFR Mutation Before Treatment

“…Our system showed that a higher proportion of GGO was linked with mutations in EGFR , consistent with most previous study findings. 8,9,22 However, some previous studies have reported that either no significant correlation was observed between mutations in EGFR and GGO 23 or mutations in EGFR were more common in lesions with >50% solid component. 24,25 The difference could be a result of insufficient recruitment of early-stage patients, or because different definitions were used for the quantification and classification of GGO.…”

Air-containing space: significantly in predicting EGFR mutation for early lung adenocarcinoma appearing as subsolid nodule

“…Molecular targeted therapy has been proved to effectively prolong progression-free survival of patients with lung adenocarcinoma (13,14). Recent studies have attempted to associate clinical, radiological features with EGFR mutations of lung adenocarcinomas with aim to determine predictors for effective EGFR status in a non-invasive way (15)(16)(17). In our study, we found that smoking history, tumor size and air-containing space were signi cant independent factors relevant to EGFR mutations in patients with early-stage lung adenocarcinoma.…”