Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase

Rizzetti, Danize Aparecida; Martin, Anastasia; Corrales, Patricia; Fernández, Francisca; Simões, Maylla Ronacher; Peçanhã, Franck Maciel; Vassallo, Dalton Valentim; Miguel, Marta; Wiggers, Giulia Alessandra

doi:10.1016/j.toxlet.2017.10.001

Cited by 33 publications

(33 citation statements)

References 62 publications

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“…On the contrary, treatment of ZFR with HEW1, despite the improvement of vascular function, did affect neither the involvement of NO in vascular responses nor the oxidative stress. Since COX‐2‐derived prostanoids play a major role in vascular alterations observed in cardiovascular diseases (Félétou, Huang, & Vanhoutte, ), and in previous studies HEW1 has demonstrated a reduction in the COX‐2 participation on cardiovascular system of Hg‐ and Al‐ treated rats (Rizzetti et al, ; Martinez et al, in press), it is possible to postulate that COX‐prostanoids pathway could be involved in the HEW1 mechanisms in our study.…”

Section: Discussionmentioning

confidence: 53%

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Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

et al. 2019

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Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost‐effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium‐emitted fluorescence, NOX‐1 mRNA levels by qRT‐PCR, angiotensin‐converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Practical applications Egg white is a good source of bioactive peptides, some of them with high antioxidant activity. They may be used as functional foods ingredients and could serve as an alternative therapeutic option to decrease some Metabolic Syndrome‐related complications. This study suggests that these hydrolysates could be an interesting non‐pharmacological tool to control cardiovascular complications related to Metabolic Syndrome.

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Section: Discussionmentioning

confidence: 53%

“…The blood pressure levels achieved in ZFR of this study, although higher than ZLR, did not reach levels of hypertension. However, HEW1 was able to prevent the increase of blood pressure in other experimental models (Rizzetti et al, ; Martinez et al, in press).…”

Section: Discussionmentioning

confidence: 91%

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

et al. 2019

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“…Similarly, ROS/RNS have been reported to cause endothelial dysfunction, vascular remodeling, arterial stiffness, arteriosclerosis, and hypertension . Uncoupling of endothelial nitric oxide synthase (eNOS) and activation of reduced form of NADPH oxidase have been reported to aggravate the production of superoxide anion radicals (O 2 − ) from the vascular endothelium, thereby promoting vascular smooth muscle cell proliferation, migration, differentiation, and atherosclerosis …”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

Oyagbemi

Omóbòwálé

Ola‐Davies

et al. 2018

Environmental Toxicology

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Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in the environment are found in the air, water, and land. In the study, forty‐male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group which was given normal saline, Group B was exposed to 300 ppm of NaF in drinking water, while Groups C and D received NaF along Rutin (100 mg/kg and 200 mg/kg) orally daily for a week. Administration of NaF alone led to significant increases in blood pressure, and deceased serum nitric oxide. Immunohistochemistry revealed higher expressions of kidney injury molecule I (Kim‐1), nuclear factor kappa beta (NF‐κB), and down regulation of nuclear factor erythroid 2‐related factor 2 (Nrf2) in rats administered NaF. Rutin co‐treatment with NaF normalized blood pressure, lowered Kim‐1 and NF‐κB expressions, and improved nitric oxide bioavailability.

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“…Rizzetti et al . () found that egg‐white hydrolysate could effectively alleviate Hg‐induced cardiovascular damage, through decreasing angiotensin converting enzyme (ACE) activity.…”

Section: Introductionmentioning

confidence: 99%

“…The peptides derived from egg-white were reported to have anti-cancer (Yi et al, 2003), anti-hypertension (Miguel et al, 2006), antibacterial (Baron et al, 2014) and other functions. Rizzetti et al (2017) found that egg-white hydrolysate could effectively alleviate Hg-induced cardiovascular damage, through decreasing angiotensin converting enzyme (ACE) activity.…”

Section: Introductionmentioning

confidence: 99%

Identification of antioxidant peptides derived from egg‐white protein and its protective effects on H₂O₂‐induced cell damage

Zhang

Wang

et al. 2019

Int J of Food Sci Tech

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Summary To identify novel antioxidant peptides from egg‐white protein and investigate antioxidant mechanism, the hydrolysate of egg‐white protein was purified by ultrafiltration and a Sephadex G‐15 column. The peptides VYLPR, EVYLPR, VEVYLPR and VVEVYLPR were identified from the fraction with the highest antioxidant activity. The Results showed that the peptide VYLPR exhibited the strongest protective effect on HEK‐293 cells. The viability of cells recovered to 97.45 ± 1.98% with pre‐treatment of 20 μm VYLPR. We further investigated antioxidant mechanism. The results showed VYLPR could inhibit lipid peroxidation process, maintain cell membrane integrity, inhibit intracellular LDH activity, reduce MDA content, and improve the activity of antioxidant enzyme T‐SOD and GSH‐Px. This work could help researchers in understanding antioxidant mechanism of peptides and also contribute to developing functional egg‐white product.

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Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase

Cited by 33 publications

References 62 publications

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

Identification of antioxidant peptides derived from egg‐white protein and its protective effects on H₂O₂‐induced cell damage

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Egg white-derived peptides prevent cardiovascular disorders induced by mercury in rats: Role of angiotensin-converting enzyme (ACE) and NADPH oxidase

Cited by 33 publications

References 62 publications

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Egg white hydrolysates improve vascular damage in obese Zucker rats by its antioxidant properties

Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats

Identification of antioxidant peptides derived from egg‐white protein and its protective effects on H2O2‐induced cell damage

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Identification of antioxidant peptides derived from egg‐white protein and its protective effects on H₂O₂‐induced cell damage