Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Ruff, Kevin J.; Winkler, Anne E.; Jackson, Robert W.; DeVore, Dale P.; Ritz, Barry W.

doi:10.1007/s10067-009-1173-4

Cited by 80 publications

(63 citation statements)

References 29 publications

(22 reference statements)

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“…And almost 20% of the study population experienced a 50% improvement in pain-related questions by the end of the study (60 days) (not shown). These results align well with results from previous clinical studies of NEM ® that were conducted in the U.S. [6,7].…”

Section: Discussionsupporting

confidence: 90%

“…In previous trials with NEM ® [6,7], the standard deviation for the study subjects for pain (within the inclusion range of this study) averaged 34.6%. We hoped to be able to detect a 1.5 point difference from baseline within the 10-point Likert scale.…”

Section: Discussionmentioning

confidence: 57%

“…Most of these treatments have shown limited effectiveness in randomized controlled clinical trials (RCTs) [2][3][4][5] or are known to have significant and sometimes severe side effects. NEM ® brand eggshell membrane has previously demonstrated good efficacy in relieving pain and stiffness associated with OA of the knee in an RCT [6] and has shown similar efficacy in limited trials for other affected joints [7].…”

Section: Introductionmentioning

confidence: 99%

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NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Danesch¹

2014

J Arthritis

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Objective: NEM ® brand eggshell membrane is a novel dietary supplement ingredient that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joints. A six center, open label clinical study was conducted to evaluate the efficacy and safety of NEM ® as a treatment for pain and inflexibility associated with osteoarthritis of the knee and/or hip in a European population.Methods: Forty-four subjects received oral NEM ® 500 mg once daily for eight weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM ® in relieving general pain associated with moderate osteoarthritis of the knee and/or hip at 10,30 and 60 days utilizing a 10-question abbreviated questionnaire based on the WOMAC osteoarthritis questionnaire. Results: Supplementation with NEM® produced a significant treatment response from baseline at 10 days (Q1-6 and Q9) (8.6% to 18.1% improvement) and at 30 and 60 days for all nine pain-related questions evaluated (22.4% to 35.6% improvement) and at 30 and 60 days for stiffness (Q10)(27.4% to 29.3% improvement). In a Patient's Global Assessment, greater than 59% of patients rated the efficacy of NEM ® as good or very good following 60 days of supplementation. Physicians also rated the treatment effective in subjects, with greater than 75% having moderate or significant improvement from baseline after 60 days. There were no serious adverse events reported during the study and the treatment was reported to be well tolerated. Conclusions: Supplementation with NEM® significantly reduced pain, both rapidly (10 days) and continuously (60 days) demonstrating that it is a safe and effective therapeutic option for the treatment of pain associated with osteoarthritis of the knee and/or hip. Results from previous clinical studies on NEM ® can likely be extended to the broader European population.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Danesch¹

2014

J Arthritis

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“…The eggshell membrane is one of the food supplements that have had very good results in this sense [2][3][4][5]. Eggshell membrane is comprised of a large part of collagen, mainly type I, V and X [6][7][8]; glycosaminoglycans (hyaluronic acid, chondroitin sulfate and different proteins that are involved in the antiinflammatory and immune system regulation ability of the eggshell membrane (lysozyme, ovotransferrin, ovocleidin-17 and ovocleidin-116) [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of 50 Days Ovomet Supplementation on Biomechanical Parameters and Subjective Pain Perception among Old Institutionalized Patients. A Preliminary Study

Aguirre¹,

Quintana²,

Fenaux³

et al. 2017

J Osteopor Phys Act

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According to previous published works, the eggshell membrane has shown a positive effect on the joint pain relief. In this study, several tests were performed to measure the effect of Ovomet ® (eggshell membrane) supplementation on the subjective perception and biomechanical variables in institutionalized patients of advanced age before and after 50 days of 300 mg Ovomet ® administration. The aim was to demonstrate and verify the protective and regenerative effects of Ovomet ® on the joints. To measure this effects some pain perception questionnaires were performed and biomechanical variables such as muscle strength and power in knee extension, linear stiffness of the Achilles tendon (AT) by ultrasound, muscle stiffness by means of sensor in two different manoeuvers were carried out. In conclusion, the daily intake of 300 mg Ovomet ® during 50 days showed a positive effect on the linear stiffness of the AT in institutionalized elderly patients showing the usefulness of the echography technique of linear stiffness of the AT to study the factors that increase the protection capacity of the joints.

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“…5,6 Eggshell membrane is primarily composed of fibrous proteins such as collagen type I. 7 However, eggshell membranes have also been shown to contain glycosaminoglycans, such as dermatan sulfate, chondroitin sulfate, 8 and hyaluronic acid, 9 and sulfated glycoproteins, including hexosamines such as glucosamine.…”

Section: Introduction Tmentioning

confidence: 99%

Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-α Levels After In Vitro Digestion

Benson

Ruff²,

Jensen

2012

Journal of Medicinal Food

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Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Abstract: Natural Eggshell Membrane (NEM®) is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium.

Cited by 80 publications

References 29 publications

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Effects of 50 Days Ovomet Supplementation on Biomechanical Parameters and Subjective Pain Perception among Old Institutionalized Patients. A Preliminary Study

Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-α Levels After In Vitro Digestion

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