We prove general uniqueness results for radial solutions of linear and nonlinear equations involving the fractional Laplacian (−Δ)s with s ∊ (0,1) for any space dimensions N ≥ 1. By extending a monotonicity formula found by Cabré and Sire , we show that the linear equation
(−Δ)su+Vu=0 in ℝN
has at most one radial and bounded solution vanishing at infinity, provided that the potential V is radial and nondecreasing. In particular, this result implies that all radial eigenvalues of the corresponding fractional Schrödinger operator H = (−Δ)s + V are simple. Furthermore, by combining these findings on linear equations with topological bounds for a related problem on the upper half‐space ℝ+N+1, we show uniqueness and nondegeneracy of ground state solutions for the nonlinear equation
−Δ)sQ+Q−|Q|αQ=0 in ℝN
for arbitrary space dimensions N ≥ 1 and all admissible exponents α > 0. This generalizes the nondegeneracy and uniqueness result for dimension N = 1 recently obtained by the first two authors and, in particular, the uniqueness result for solitary waves of the Benjamin‐Ono equation found by Amick and Toland .© 2016 Wiley Periodicals, Inc.