Eight SNVs in NF-κB pathway genes and their different performances between subclinical mastitis and mixed Chinese Holstein cows

Chen, Ling; Han, Yujiao; Chen, Yu; Li, Zhixiong; Wang, Hongliang; Liu, Yu; He, Hongbin; Chen, Si; Liu, Xiaolin

doi:10.1016/j.gene.2014.11.011

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…If those indexes are large, the genetic variation at a given locus will be high (Fang et al, 2012). According to the classification of PIC (Chen et al, 2015), the SNPs detected in the current study (except A3164C) presented moderate (0.25＜PIC＜0.5) polymorphisms in pigeon, indicating that MyoD1 is rich in polymorphisms.…”

Section: Discussionmentioning

confidence: 63%

Association of MyoD1 Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (Columba livia)

et al. 2019

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Myogenic differentiation 1 (MyoD1) belongs to the MyoD family and plays a key role in myogenesis and consequently, in determining muscle fiber characteristics. In this study, single nucleotide polymorphisms (SNPs) in the exons of MyoD1 were identified in 200 domestic pigeons (Columba livia) by direct DNA sequencing, and the association between MyoD1 polymorphisms and meat quality traits was analyzed. We found four novel variations (A2967G, G3044A, A3164C, and C3311G) in exon 3. The SNP A2967G is a synonymous mutation, while the other 3 SNPs are located in the 3′untranslated region. The analysis revealed 3 genotypes, in which allele A was the predominant allele in the SNP A2967G, while allele B was the predominant allele in the SNPs G3044A and A3164C. The mutations A2967G and G3044A were significantly associated with meat quality traits in pigeon. Pigeons with AA or AB genotypes had higher breast muscle concentrations of inosinic acid and intramuscular fat than those of BB genotype. Moreover, these 2 SNPs had significant effects on MyoD1 mRNA expression. The SNPs A2967G and G3044A were organized into 4 haplotypes, which formed 7 diplotypes. Association analysis showed that the diplotypes were not significantly associated with meat quality traits. Our results implied that associations do exist between MyoD1 gene polymorphisms and meat quality traits in domestic pigeons, and the AA and AB genotypes could be applied as genetic markers in marker-aid pigeon breeding.

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Section: Discussionmentioning

confidence: 63%

Association of MyoD1 Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (Columba livia)

et al. 2019

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“…Drawing conclusions from these studies is hindered by extensive differences in individual responses between cows, even when the cows came from the same herd, with similar genetic backgrounds and similar age [ 24 ]. Recently, important gene-wide association studies between DNA polymorphisms and mastitis susceptibility in dairy cows, and these have been correlated with changes in gene expression [ 25 – 27 ]. While, in the same animal, responses are similar between repeated infections [ 28 ], different animals will respond inconsistently to E .…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of Transcriptional Responses to Mastitis-Causing Escherichia coli

2016

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Bovine mastitis is a widespread disease in dairy cows, and is often caused by bacterial mammary gland infection. Mastitis causes reduced milk production and leads to excessive use of antibiotics. We present meta-analysis of transcriptional profiles of bovine mastitis from 10 studies and 307 microarrays, allowing identification of much larger sets of affected genes than any individual study. Combining multiple studies provides insight into the molecular effects of Escherichia coli infection in vivo and uncovers differences between the consequences of E. coli vs. Staphylococcus aureus infection of primary mammary epithelial cells (PMECs). In udders, live E. coli elicits inflammatory and immune defenses through numerous cytokines and chemokines. Importantly, E. coli infection causes downregulation of genes encoding lipid biosynthesis enzymes that are involved in milk production. Additionally, host metabolism is generally suppressed. Finally, defensins and bacteria-recognition genes are upregulated, while the expression of the extracellular matrix protein transcripts is silenced. In PMECs, heat-inactivated E. coli elicits expression of ribosomal, cytoskeletal and angiogenic signaling genes, and causes suppression of the cell cycle and energy production genes. We hypothesize that heat-inactivated E. coli may have prophylactic effects against mastitis. Heat-inactivated S. aureus promotes stronger inflammatory and immune defenses than E. coli. Lipopolysaccharide by itself induces MHC antigen presentation components, an effect not seen in response to E. coli bacteria. These results provide the basis for strategies to prevent and treat mastitis and may lead to the reduction in the use of antibiotics.

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“…Bovine mastitis is the most frequent and costly disease that affects the dairy industry around the world (Correa and Marin, 2002;Cerón-Muñoz et al, 2002;Wellenberg et al, 2002) which describes an inflammatory reaction in the mammary gland caused by a spectrum of pathogens that penetrate the nipple canal (Kitchen, 1981;Chen et al, 2015). The severity of inflammation depends on the causative agent and the response of the host (Burvenich et al, 2003;Bannerman et al, 2004;Barkema et al, 2006;Petzl et al, 2008) producing pain and stress to the cows, resulting in a decrease in production and in the quality of the milk, as it changes it´s taste and normal bacterial load increases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bacteria Associated with Infectious Bovine Mastitis in Some Milk-Producing Municipalities in Norte de Santander Department

Cajiao¹,

Rojas²,

Capacho³

2018

AJFST

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A study was carried out to establish the prevalence of bacteria associated with infectious bovine mastitis in some milk-producing municipalities in Norte de Santander Department, from which possible species of Staphylococcus, Streptococcus and Enterobacteria were isolated and identified. One hundred and sixty three samples which were inoculated by depletion in: Blood Agar and EMB Agar were analyzed and incubated at 37°C/24 h. Preliminary identification of the bacteria was done through conventional biochemical tests and RapID™ ONE System and RapID System PLUS STAPH. A total of 207 bacteria were isolated;

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Eight SNVs in NF-κB pathway genes and their different performances between subclinical mastitis and mixed Chinese Holstein cows

Cited by 12 publications

References 31 publications

Association of <i>MyoD1</i> Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (<i>Columba livia</i>)

Association of <i>MyoD1</i> Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (<i>Columba livia</i>)

Meta-Analysis of Transcriptional Responses to Mastitis-Causing Escherichia coli

Prevalence of Bacteria Associated with Infectious Bovine Mastitis in Some Milk-Producing Municipalities in Norte de Santander Department

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