Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem <sup>3</sup>He

Lehmann, F.; Knitz, Frank; Weiler, Norbert; Kk, Gast; Ley, S.; Schmiedeskamp, Jörg; Heußel, CP; Me, Bellemann; Kauczor, HU; Schreiber, Laura M.

doi:10.1055/s-2004-813561

Cited by 16 publications

(4 citation statements)

References 16 publications

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“…b Ventilation image with 3 He: there are no apparent ventilation defects, thus together with the ce-MRA demonstrating the mismatch between macrocirculation and ventilation. c The O 2 parameter map shows increased intrapulmonary PO 2 in the region with disturbed perfusion (➔) when compared with areas with fewer perfusion deficits (υ) these first results, functional 3 He MR imaging including techniques to utilize the oxygen-sensitivity of intraalveolar spin hyperpolarization may develop into a quick, non-invasive and easily repeatable method to assess the regional matching of ventilation with perfusion, at least in those parts of the lung reached by inhaled 3 He, and to estimate local oxygen uptake from selected regions within the lung parenchyma [39][40][41].…”

Section: Functional Imaging With Noble Gas Mr Imagingmentioning

confidence: 99%

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

et al. 2006

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Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe disease that has been ignored for a long time. However, with the development of improved therapeutic modalities, cardiologists and thoracic surgeons have shown increasing interest in the diagnostic work-up of this entity. The diagnosis and management of chronic thromboembolic pulmonary hypertension require a multidisciplinary approach involving the specialties of pulmonary medicine, cardiology, radiology, anesthesiology and thoracic surgery. With this approach, pulmonary endarterectomy (PEA) can be performed with an acceptable mortality rate. This review article describes the developments in magnetic resonance (MR) imaging techniques for the diagnosis of chronic thromboembolic pulmonary hypertension. Techniques include contrast-enhanced MR angiography (ce-MRA), MR perfusion imaging, phase-contrast imaging of the great vessels, cine imaging of the heart and combined perfusion-ventilation MR imaging with hyperpolarized noble gases. It is anticipated that MR imaging will play a central role in the initial diagnosis and follow-up of patients with CTEPH.

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Section: Functional Imaging With Noble Gas Mr Imagingmentioning

confidence: 99%

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

et al. 2006

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“…Verschiedene Perfusionsverfahren wurden insbesondere zur zerebrovaskulären Bildgebung eingesetzt. Die Lungenfunktion kann in Bezug auf Perfusion [6], Ventilation [7] und Sauerstoffpartialdruck [8] charakterisiert werden. Im Bereich von Tumordiagnostik erlaubt die dynamische kontrastmittelgestützte MR-Bildgebung eine Charakterisierung der Mikrozirkulation des Tumors [9].…”

Section: Gewebefunktionunclassified

Parametrische biomedizinische Bildgebung - was macht die Qualität quantitativer radiologischer Verfahren aus?

Glüer

Barkmann

Hahn

et al. 2006

Fortschr Röntgenstr

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Quantitative parametric imaging approaches provide new perspectives for radiological imaging. These include quantitative 2D, 3D, and 4D visualization options along with the parametric depiction of biological tissue properties and tissue function. This allows the interpretation of radiological data from a biochemical, biomechanical, or physiological perspective. Quantification permits the detection of small changes that are not yet visually apparent, thus allowing application in early disease diagnosis and monitoring therapy with enhanced sensitivity. This review outlines the potential of quantitative parametric imaging methods and demonstrates this on the basis of a few exemplary applications. One field of particular interest, the use of these methods for investigational new drug application studies, is presented. Assessment criteria for judging the quality of quantitative imaging approaches are discussed in the context of the potential and the limitations of these methods. While quantitative parametric imaging methods do not replace but rather supplement established visual interpretation methods in radiology, they do open up new perspectives for diagnosis and prognosis and in particular for monitoring disease progression and therapy.

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Section: Dynamische Ventilationunclassified

“…Durch die computergestützte Nachverarbeitung der Bilddaten [75] während der Respiration gelingt eine anatomisch korri-gierte quantitative Analyse von lokalen dynamischen Parametern. Dazu ist eine Homogenisierung der Lungengrößen erforderlich, die eine Messung in koronarer Ebene voraussetzt [75]. Die lokalen Lungenfunktionswerte beschreiben die Zeit, die Gas von der Trachea bis zur Ausbreitung im Parenchym benötigt, und eine eventuelle intrapulmonale Umverteilung (Abbildung 5) [76].…”

Section: Dynamische Ventilationunclassified

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

Gast

Morbach²,

Kauczor

et al. 2005

Med Klin

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Lung imaging is traditionally done using X-ray-based methods, since MRI is limited by low proton density as well as inherent magnetic field inhomogeneities of the lung tissue. After introduction of MRI using hyperpolarized noble gases, a totally new field of MRI of the chest has rapidly evolved. These techniques reveal new functional information of the lungs, which could not be obtained before. The first part of this review describes the underlying MR technology explaining distribution of static ventilation, dynamic distribution of ventilation, lung microstructure (apparent diffusion coefficient [ADC]), measurement of oxygen partial pressure (pO(2)), and safety. The clinical potential is afterwards demonstrated in the second part. Therefore, the effort in normal lungs and the mainly focused diseases chronic obstructive pulmonary disease (COPD), smoker's lung, cystic fibrosis, asthma, lung transplantation, and pulmonary embolism are reported.

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Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem ³He

Cited by 16 publications

References 16 publications

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

Parametrische biomedizinische Bildgebung - was macht die Qualität quantitativer radiologischer Verfahren aus?

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

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Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem 3He

Cited by 16 publications

References 16 publications

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

Chronic thromboembolic pulmonary hypertension — assessment by magnetic resonance imaging

Parametrische biomedizinische Bildgebung - was macht die Qualität quantitativer radiologischer Verfahren aus?

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

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Ein Auswerteprogramm zur quantitativen Untersuchung der Lungenventilation mittels dynamischer MRT von hochpolarisiertem ³He