EJNMMI Physics - an editor's perspective

Beyer, Thomas; Carrió, I

doi:10.1186/2197-7364-1-1

Cited by 16 publications

(9 citation statements)

References 6 publications

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“…This marriage of two modalities with very different physics allows the development of many novel synergistic techniques and applications including MR-assisted PET motion correction (Fürst et al ., 2015; Polycarpou et al ., 2014; Huang et al ., 2014; Fayad et al ., 2014; Petibon et al ., 2014; Bickell et al ., 2014), MR-assisted partial volume correction (Yan et al ., 2015; Bickell et al ., 2014; Wang and Fei, 2012), PET guided MR spectroscopy (Zhang et al ., 2014), and PET-MR joint reconstruction (Knoll et al ., 2014). …”

Section: Introductionmentioning

confidence: 99%

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR

et al. 2015

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Due to the lack of signal from solid bone in normal MR sequences for the purpose of MR-based attenuation correction, investigators have proposed using the ultrashort echo time (UTE) pulse sequence, which yields signal from bone. However, UTE-based segmentation approach might not fully capture the intra- and inter-subject bone density variation, which will inevitably lead to bias in reconstructed PET images. In this work, we investigated using the Water- And fat-Suppressed proton Projection Imaging (WASPI) sequence to obtain accurate and continuous attenuation for the bones. This approach is capable to account for intra- and inter-subject bone attenuation variations. Using data acquired from a phantom, we have found that that attenuation correction based on WASPI sequence is more accurate and precise when compared to either conventional MR attenuation correction or UTE based segmentation approaches.

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Section: Introductionmentioning

confidence: 99%

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR

et al. 2015

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“…However, PRISM and similar CS methods capture correlation as low-rank characteristics which are rather general but not very specific. Other methods in the literature, such as [22], cannot well address the joint image reconstruction problem over imaging modalities. Here we suggest use of structural coupling to reflect local similarity more specifically and more effectively for joint multi-modality image reconstruction.…”

Section: Methodsmentioning

confidence: 99%

Simultaneous CT-MRI Reconstruction for Constrained Imaging Geometries Using Structural Coupling and Compressive Sensing

Zhao

Bennett

et al. 2016

IEEE Trans. Biomed. Eng.

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Objective A unified reconstruction framework is presented for simultaneous CT-MRI reconstruction. Significance Combined CT-MRI imaging has the potential for improved results in existing preclinical and clinical applications, as well as opening novel research directions for future applications. Methods In an ideal CT-MRI scanner, CT and MRI acquisitions would occur simultaneously, and hence would be inherently registered in space and time. Alternatively, separately acquired CT and MRI scans can be fused to simulate an instantaneous acquisition. In this study, structural coupling and compressive sensing techniques are combined to unify CT and MRI reconstructions. A bidirectional image estimation method was proposed to connect images from different modalities. Hence, CT and MRI data serve as prior knowledge to each other for better CT and MRI image reconstruction than what could be achieved with separate reconstruction. Results Our integrated reconstruction methodology is demonstrated with numerical phantom and real-dataset based experiments, and has yielded promising results.

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“…In a pre-evaluation a threshold in which 90% of cases were rated with “good to excellent” image quality was defined [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

“…In a pre-evaluation to this presented study, it was shown that NECR measured in patients can predict clinically perceived image quality in PET-imaging and a corresponding FDG-activity threshold above which the acquired PET images have good-to-excellent perceived quality in more than 90% of patients [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Dose Optimization in TOF-PET/MR Compared to TOF-PET/CT

Queiroz

Delso²,

Wollenweber³

et al. 2015

PLoS ONE

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PurposeTo evaluate the possible activity reduction in FDG-imaging in a Time-of-Flight (TOF) PET/MR, based on cross-evaluation of patient-based NECR (noise equivalent count rate) measurements in PET/CT, cross referencing with phantom-based NECR curves as well as initial evaluation of TOF-PET/MR with reduced activity.Materials and MethodsA total of 75 consecutive patients were evaluated in this study. PET/CT imaging was performed on a PET/CT (time-of-flight (TOF) Discovery D 690 PET/CT). Initial PET/MR imaging was performed on a newly available simultaneous TOF-PET/MR (Signa PET/MR). An optimal NECR for diagnostic purposes was defined in clinical patients (NECRP) in PET/CT. Subsequent optimal activity concentration at the acquisition time ([A]0) and target NECR (NECRT) were obtained. These data were used to predict the theoretical FDG activity requirement of the new TOF-PET/MR system. Twenty-five initial patients were acquired with (retrospectively reconstructed) different imaging times equivalent for different activities on the simultaneous PET/MR for the evaluation of clinically realistic FDG-activities.ResultsThe obtained values for NECRP, [A]0 and NECRT were 114.6 (± 14.2) kcps (Kilocounts per second), 4.0 (± 0.7) kBq/mL and 45 kcps, respectively. Evaluating the NECRT together with the phantom curve of the TOF-PET/MR device, the theoretical optimal activity concentration was found to be approximately 1.3 kBq/mL, which represents 35% of the activity concentration required by the TOF-PET/CT. Initial evaluation on patients in the simultaneous TOF-PET/MR shows clinically realistic activities of 1.8 kBq/mL, which represent 44% of the required activity.ConclusionThe new TOF-PET/MR device requires significantly less activity to generate PET-images with good-to-excellent image quality, due to improvements in detector geometry and detector technologies. The theoretically achievable dose reduction accounts for up to 65% but cannot be fully translated into clinical routine based on the coils within the FOV and MR-sequences applied at the same time. The clinically realistic reduction in activity is slightly more than 50%. Further studies in a larger number of patients are needed to confirm our findings.

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EJNMMI Physics - an editor's perspective

Cited by 16 publications

References 6 publications

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR

Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR

Simultaneous CT-MRI Reconstruction for Constrained Imaging Geometries Using Structural Coupling and Compressive Sensing

Dose Optimization in TOF-PET/MR Compared to TOF-PET/CT

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