El colesterol HDL: ¿un nuevo objetivo terapéutico en el manejo de las dislipidemias y la ateroesclerosis?

E, María del Rosario Laris; L, Antonio Arteaga; M, Ada Cuevas; R, Attilio Rigotti

doi:10.4067/s0034-98872005000700011

Cited by 6 publications

(6 citation statements)

References 43 publications

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“…HDL-c is an excellent marker of the risk of arteriosclerosis and especially of coronary disease, and in a large number of epidemiological studies it is the lipid risk factor with the greatest predictive power: it is the most frequent lipid disorder in persons with premature coronary disease. When low HDL-c accompanies elevated LDL-c, that is, when the LDL-c/HDL-c quotient is greater than 5, the atherogenic risk is very high, and is doubled in the presence of hypertriglyceridemia [14]. Commonly associated medical conditions are diabetes mellitus, chronic kidney disease, and chronic inflammatory disorders like rheumatoid arthritis.…”

Section: Resultsmentioning

confidence: 99%

Lipid profile of Mexican children with Down syndrome

2021

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Introduction Down syndrome (DS) is associated with various congenital anomalies and metabolic alterations, such as dyslipidemias, that can lead to cardiovascular disease in adulthood. This study was designed to describe the lipid concentrations and the frequency of dyslipidemias in children with DS. Materials and methods The sample included 386 patients, 52.4% male. The study was carried out on children with DS, aged 2–18 years old, who were patients at the Mexican National Institute of Pediatrics between May 2016 and June 2017. Their height and weight were recorded, and their serum cholesterol, HDL cholesterol, and triglyceride levels were determined. Results Of the total patients included, 57.5% had some type of dyslipidemia, 32.6% isolated and 24.9% combined. The most common alteration, considering both isolated and combined dyslipidemias, was low HDL, in 45.9%, followed by hypertriglyceridemia, in 26.2%. Among those with combined dyslipidemia, high TG with low HDL-c was the most common, in 17.9%. A significant association was found between dyslipidemia and obesity, as well as between dyslipidemia and central obesity. The percentiles of lipid values are reported. Conclusion The presence of an unfavorable lipid profile is common in pediatric patients with Down syndrome, especially low HDL cholesterol and high triglycerides.

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Section: Resultsmentioning

confidence: 99%

Lipid profile of Mexican children with Down syndrome

2021

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Section: Otras Alternativas Hipolipemiantes En Desarrollounclassified

“…Además, existen en fase avanzada de desarrollo preclínico y clínico moduladores específicos del metabolismo de HDL (p.e., torcetrapib) 46 . El torcetrapib es inhibidor de la proteína responsable de la transferencia de colesterol éster y triglicéridos (CETP) entre lipoproteínas a nivel intravascular, regulando la remodelación de las HDL y el transporte retrógrado del colesterol 46 . En los primeros estudios humanos se ha demostrado que el torcetrapib aumenta los niveles de colesterol de HDL entre 60-100% con respecto a los niveles basales, sin apreciarse efectos secundarios significativos 47,48 .…”

Section: Otras Alternativas Hipolipemiantes En Desarrollounclassified

Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico

2006

Rev. méd. Chile

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Primary and secondary prevention trials have clearly demonstrated that lowering serum cholesterol levels with statins reduces the incidence of cardiovascular events. Recent studies plus post hoc analysis of previous clinical trials show that risk reduction is proportional to the magnitude of LDL cholesterol lowering. Therefore, new recommendations of the National Cholesterol Education Program (USA) have defined a category of patients with very high cardiovascular risk, who should achieve serum LDL cholesterol levels below 70 mg/dl. This proposal will require new and more efficient pharmacologic strategies to attain the increasingly strict therapeutic goals for LDL cholesterol. This article reviews the clinical studies that support the use of intensive lipid lowering therapy to reduce cardiovascular risk. An effective reduction of serum cholesterol can be obtained using statins in high doses or a combination of hypolipidemic drugs with different mechanisms of action.

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“…Así, en caninos, felinos, equinos, bovinos y ratones predominan las HDL, dándoles el nombre de mamíferos HDL, en contraste con el humano, cerdos, monos, conejos, cobayos, hámster y otros de vida silvestre donde predomina el colesterol LDL (Maldonado et al, 2001;Coppo et al, 2003). En el humano, el consumo de alimentos ricos en colesterol genera un aumento en los niveles de colesterol LDL, conllevando a un mayor riesgo de enfermedades cardiovasculares y ateroesclerosis (Colpo, 2005;Laris et al, 2005). No obstante, en el canino, las HDL ayudan a eliminar el exceso de apoproteínas y trasladan el colesterol de los tejidos extrahepáticos al hígado, mediante el proceso de transporte inverso del colesterol, el cual se considera esencial para el mantenimiento del equilibrio de los esteroles, reduciendo el riesgo aterogénico en esta especie (Osorio et al, 2010).…”

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Comparación entre el Método Directo y la Fórmula de Friedewald para Determinar los Niveles de Colesterol LDL en Caninos

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Vinasco

2014

Rev. investig. vet. Perú

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RESUMENEl objetivo del estudio fue comparar el método Directo con la fórmula de Friedewald para la determinación de colesterol LDL en caninos. Se tomaron 185 muestras de sangre de caninos adultos en ayuno y sin restricción de sexo. Se extrajo el suero y se determinaron los niveles de colesterol LDL con los dos métodos. El promedio, desviación estándar y valores mínimos y máximos por el método Directo fueron de 49.2 ± 16.7, 14.6 y 96.0 mg/ dl, respectivamente, y por la fórmula de Friedewald fueron de 65.2 ± 31.5, 4.6 y 184.2 mg/ dl, respectivamente, habiendo diferente estadística (p<0.05) entre métodos. Se recomienda el uso del método directo para la determinación de los niveles de colesterol LDL en caninos.Palabras clave: colesterol LDL, perro, método directo, fórmula de Friedewald ABSTRACTThe aim of this study was to compare the Direct method and the Friedewald formula method for the determination of LDL cholesterol in dogs. Blood samples were collected in 185 fasted dogs without sex restriction. Serum was extracted and levels of LDL cholesterol were determined by the two methods. The mean, standard deviation, and minimum and maximum values by the Direct method were 49.2 ± 16.7, 14.6 and 96.0 mg/dl, respectively, and by the Friedewald method were 65.2 ± 31.5, 4.6 and 184.2 mg/dl, respectively, with significant difference between the methods (p<0.05). The Direct method is recommended for determining LDL cholesterol levels in dogs.

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El colesterol HDL: ¿un nuevo objetivo terapéutico en el manejo de las dislipidemias y la ateroesclerosis?

Abstract: (Rev Méd Chile 2005; 133: 823-32).

Cited by 6 publications

References 43 publications

Lipid profile of Mexican children with Down syndrome

Lipid profile of Mexican children with Down syndrome

Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico

Comparación entre el Método Directo y la Fórmula de Friedewald para Determinar los Niveles de Colesterol LDL en Caninos

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