Elastase-triggered H₂S delivery from polymer hydrogels

Abstract

A polymer hydrogel was prepared that underwent a gel-to-sol transition in response to the enzyme elastase, triggering release of H2S from incorporated S-aroylthiooximes.

Hierarchical Ion/Electron Networks Enable Efficient Red Phosphorus Anode with High Mass Loading for Sodium Ion Batteries

“…The peaks centered at 134.4 eV and 135.1 eV are assigned to POC and PO bond, respectively, [ 50 ] which is probably formed by surface oxidation during air exposure. [ 33,49,50 ] POC bond can be further confirmed by C 1s spectra at 286.1 eV (Figure S10, Supporting Information). In addition, we also collected the XPS spectrum of WDC@RP and the RP deposited CNTs (CNTs@RP) as contrast samples (Figure S11, Supporting Information), both of which show the signal of POC bond.…”

“…These results further demonstrated the advantages of our designed hierarchical structures of WDC/CNTs@RP electrode toward relieving the volume expansion and keeping the integrity of the whole electrode during cycling processes. [ 16,33,34 ] To clarify the capacity contribution from the conductive WDC and CNTs, the WDC/CNTs, WDC, and CNTs carbon matrixes were also applied as the anode for SIBs (Figure S20, Supporting Information). Obviously, the delivered specific capacities of those frameworks are very limited (below 90 mA h g −1 ), implying the capacity contribution is mainly from RP active materials in WDC/CNTs@RP electrode.…”

“…[ 16–21 ] However, the rapid capacity decay and sluggish redox reaction kinetics of RP stemming from the large volume variation (≈300%) during sodiation/desodiation processes and the intrinsic poor electronic conductivity (≈10 −10 S cm −1 ) severely limited the practical application of RP. [ 22–28 ] Up to now, many strategies have been reported to resolve those issues, such as carbon matrixes decoration, [ 17–19,22–24,29–32 ] nanostructure engineering, [ 27,33,34 ] and heteroatom doping, [ 20,26 ] and excellent power density has been also achieved. [ 24–28 ] However, those excellent results are generally achieved by using thin electrodes with low RP mass loadings (below 1 mg cm −2 ), resulting in a diminishing energy density when other inactive components such as current collectors and separators are accounted.…”

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

“…Though lots of small molecular H 2 S donors have been developed, they usually unable to meet the requirements of in vivo applications, since the stability, water solubility, stimuli-responsive property, and toxicity of donors themselves or their byproducts are difficult to regulate at the small molecule level [ 27 ]. With the purpose to overcome these limits, various biocompatible polymers are utilized to establish H 2 S delivery systems, mainly by physically encapsulating or chemically conjugating H 2 S donors with polymeric carriers such as micelles [ 28 , 29 ], liposomes [ 30 ], nanoparticles [ 31 ], nanofibers [ 32 ], or hydrogels [ 33 ]. The main advantage of these polymeric H 2 S delivery systems is that the H 2 S releasing behaviors including releasing dosage, releasing kinetics, as well as releasing locations are effectively regulated and the biocompatibility is significantly improved without drastically changing the chemical properties of the loaded H 2 S donors.…”

Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission

“…In view of this, many organosulfur compounds have been developed over the last two decades as sustained donors of H 2 S; however, most of them are non-fluorogenic. [8][9][10][11][12][13][14] Owing to the added advantages of turnon fluorogenic H 2 S donors over non-fluorogenic donors, a few external stimuli and bio-analyte-triggered fluorogenic H 2 S donors have been reported very recently. For example, lighttriggered fluorogenic H 2 S donors including Probe 3 have been reported, enabling the real-time monitoring of H 2 S release in aqueous and cellular media (Fig.…”