Elastic Liposome Formulation for Transdermal Delivery of Rutin

Park, Soo Nam; 임명선,; 한샛별,; 권순식,; 박민아,

doi:10.15230/scsk.2012.38.2.147

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…Hydrogel hydrated the stratum corneum of the skin and increased its intercellular pore size, increasing the permeation of the agents. However, the MP in sodium phosphate buffer (PB + MP) showed a low MP permeation because of the aggregation and adsorption of MP on the lipid layer of the stratum corneum . DL2 + MP and DL2 + Gel + MP showed higher permeation of MP than PB + MP and BG + MP.…”

Section: Resultsmentioning

confidence: 99%

“…After washing, the skin portion that was not in contact with the receptor phase was removed. The stratum corneum was removed three times by the stripping method using 3 m scotch tape (3 m, Korea) . Next, these tapes were cut into pieces and extracted with 10 mL of ethanol by sonication for 1 h. The supernatant was obtained by centrifugation, evaporated using a rotary evaporator, and re‐dissolved in 1 mL receptor phase.…”

Section: Methodsmentioning

confidence: 99%

“…This molecule is a nonionic edge activator that contains a polyglyceryl group at the 3‐methylglucose, which increases membrane stability (Figure B). Recently, this stabilizer/surfactant has been used as an edge activator in deformable liposomes with particle sizes greater than 200 nm to improve their stability and deformability; these liposomes showed a high skin penetration rate . It has not been fully explained how this edge activator increases liposome deformability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Jeong

Kim

et al. 2018

Euro J Lipid Sci & Tech

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Whitening materials cannot easily cross the skin barrier (stratum corneum) to reach melanocytes in the basal layer for inhibiting melanin production. This study aims to construct a novel deformable liposome using polyglyceryl‐3‐methylglucose distearate as an edge activator and a hydrogel containing hyaluronic acid (HA) and hydroxyethyl cellulose (HEC), as well as to investigate the synergistic effect of this system on the delivery of a cysteine derivative, methyl‐2‐acetylamino‐3‐(4‐hydroxyl‐3,5‐dimethoxybenzoylthio)propanoate (MP) as a whitening agent. The optimized deformable liposome (DL2) contains 10% edge activator and has a particle size of 78.2 ± 2.7 nm, a zeta potential of −29.9 ± 1.8 mV, a polydispersity index of 0.248, and an entrapment efficiency of 90.7 ± 1.7%. MP‐loaded DL2 has higher stability and deformability than DL2 without MP, as well as exerting a higher whitening effect than that observe with MP alone. In addition, MP‐loaded DL2 is incorporated into a hydrogel in a dual drug‐delivery system and the stability after hydrogel incorporation is evaluated. In Franz cells, the MP‐loaded deformable liposome‐hydrogel complex shows the highest skin permeation and penetration of MP. Practical Applications: In general, it is very difficult for whitening agents to penetrate a skin layer for reducing skin pigmentation. It is important to transfer whitening agents to the basal layer without causing physical damage to the skin. Deformable liposomes containing 10% polyglyceryl‐3‐methylglucose distearate in a hydrogel complex maximize the skin permeation of a cysteine derivative as a whitening agent. This finding indicates that the deformable liposome‐hydrogel complex is a potential delivery system for treatment of skin hyperpigmentation. The penetration mechanism of drugs in the skin by deformable liposome‐hydrogel complexes is as follows: Hydrogel hydrates stratum corneum to secure the route of drugs or nanocarrier permeation. polyglyceryl‐3‐methylglucose distearate as an edge activator enhances the fluidity of the stratum corneum lipid layer and the deformability of liposome. The edge activator‐based deformable liposomes pass through the stratum corneum stably.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Jeong

Kim

et al. 2018

Euro J Lipid Sci & Tech

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show abstract

“…Recent reports describe the preparation of elastic nanoliposomes through the use of nonionic surfactants such as polyglyceryl-3-methylglucose distearate as an edge activator [ 17 , 18 , 19 ]. This surfactant has two alkyl chains, unlike an edge activator with a single alkyl chain that is used in conventional elastic nanoliposomes.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Hong

Han

et al. 2018

Nanomaterials

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Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems.

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“…However, the skin barrier makes it difficult to achieve an effective drug delivery via transdermal penetration. Delivery of functional materials for the suppression and delay of skin ageing in cosmetics is very important [11][12][13]. So, the development of drug delivery system has been researched actively.…”

Section: Introductionmentioning

confidence: 99%

Enhanced skin delivery of liquiritigenin and liquiritin‐loaded liposome‐in‐hydrogel complex system

Kim

Kwon

Jeon

et al. 2014

Intern J of Cosmetic Sci

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Elastic Liposome Formulation for Transdermal Delivery of Rutin

Cited by 7 publications

References 19 publications

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Enhanced skin delivery of liquiritigenin and liquiritin‐loaded liposome‐in‐hydrogel complex system

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