Elastic Properties and Surface Topography of Lymphocytes in Patients With Acute and Chronic Myeloblast Leucosis

Abstract

Shamray E. A., Ryadinskaya A.G., Belyaeva S.S AbstractThe authors studied the features of relief surface and elastic properties of lymphocytes in patients with acute myeloblast leucosis (AML) and chronic myeloblast leucosis (CML) on the stage of the treatment with the method of atomic force microscopy. In patients with AML, there was noted an increase of stiffness of cells by 64% (p <0.05) accompanied by a reduction in the number of globules and recesses on the lymphocytes membrane, and an increase in their height and width as compared with the control group. In patients with CML, the authors observed an increase of Young modulus by 123% (p<0.05) and an increase in the number of globules on the surface as compared with healthy people. The revealed features have an important meaning for understanding the pathogenesis of lymphoproliferative diseases.