Elastin peptides in aging and pathological conditions

Baud, Stéphanie; Duca, Laurent; Bochicchio, Brigida; Brassart, Bertrand; Belloy, Nicolas; Pepe, Antonietta; Dauchez, Manuel; Martiny, Laurent; Debelle, Laurent

doi:10.1515/bmc-2011-0062

Cited by 30 publications

(14 citation statements)

References 117 publications

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“…Tripeptide GHK itself, as well as its inclusion in collagen film preparations may stimulate wound healing through the increase of collagen synthesis by fibroblasts. Another peptide, i.e., peptide VVPQ derived from elastin, has a mitogenic effect on skin fibroblasts [20]. KKLRIKSKE-sequence peptides of the LG4 domain of laminin a3 contribute to epidermis repair as they induce adhesion and keratinocyte migration.…”

Section: Introductionmentioning

confidence: 99%

The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity

et al. 2019

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KTTKS is a matrikine that originates from the proteolytic hydrolysis of collagen. This peptide stimulates ECM production and types I and III collagen expression in vitro. A more stable form of KTTKS is pal-KTTKS, known as Matrixyl® or palmitoyl pentapeptide-3. A series of novel pentapeptides, analogues of KTTKS with the general formula X-KTTKS-OH(NH2), where X = acetyl, lipoyl, palmitoyl residues, was designed and synthesized. Their effect on amidolytic activity of urokinase, thrombin, trypsin, plasmin, t-PA, and kallikrein were tested. Cytotoxic tests on fibroblasts, as well as collagen and DNA biosynthesis tests for selected peptides, were also carried out. The test results showed that the most active plasmin inhibitors were palmitoyl peptides, whether in acid or amide form. No biological effects of lysine modification to arginine in the synthesized peptides were found. None of the synthesized peptides was not cytotoxic on fibroblasts, and three of them showed cell growth. These three compounds showed no concentration-activity relationship in the collagen and DNA biosynthesis assays.

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Section: Introductionmentioning

confidence: 99%

The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity

et al. 2019

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“…In the photoaged skin, elastin material is degraded by the elastase enzyme. This condition is called elastosis and is irreversible, thus the process of elastin synthesis is limited to the embryo formation [ 4 ]. Collagen fibers, on the other hand are synthesized throughout an individual’s lifetime, but in the elderly the process is not as intensive as in the young [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes

et al. 2017

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Mangiferin (2-C-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a polyphenol with strong antioxidant properties. Mangiferin is obtained from the mango tree (Mangifera indica L., Anacardiaceae). It has been proven that mangiferin exhibits many pharmacological activities. The aim of this study was to analyze the penetration of mangiferin into the human skin and through the skin. According to our knowledge, skin penetration and permeation studies of mangiferin have not been analyzed so far. Additionally, the influence of mangiferin on two Extracellular Matrix Enzymes (ECM): collagenase and elastase, was evaluated for the first time. It has been indicated that mangiferin is able to permeate the stratum corneum and penetrate into the epidermis and dermis in comparable amounts. For confirmation of the obtained results, fluorescence microscopy was successfully utilized. The analysis revealed the capability of mangiferin to reversibly inhibit elastase and collagenase activity. The mechanism of mangiferin interaction with both enzymes was estimated as a noncompetitive inhibition.

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“…38,40 In addition to playing a role in integrin-mediated mechanotransduction, the fragmentation of elastin through mechanical damage or enzymatic activity may induce a cellular response by the binding of released elastin peptides to elastin receptor complexes. 54,55 Elastin peptides have been demonstrated to induce biological effects such as chemotaxis and protease synthesis on a number of cell types, including fibroblasts. 54,56 While elastin-peptide signaling is known to impact pathologies in the lungs and vasculature, its importance in tendon or ligament is unknown.…”

Section: Mechanotransduction and Cell Signalingmentioning

confidence: 99%

“…54,55 Elastin peptides have been demonstrated to induce biological effects such as chemotaxis and protease synthesis on a number of cell types, including fibroblasts. 54,56 While elastin-peptide signaling is known to impact pathologies in the lungs and vasculature, its importance in tendon or ligament is unknown. 57,58…”

Section: Mechanotransduction and Cell Signalingmentioning

confidence: 99%

Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

Hill

Eekhoff

Brophy

et al. 2020

Journal Orthopaedic Research

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Elastic fibers are an essential component of the extracellular matrix of connective tissues. The focus of both clinical management and scientific investigation of elastic fiber disorders has centered on the cardiovascular manifestations due to their significant impact on morbidity and mortality. As such, the current understanding of the orthopedic conditions experienced by these patients is limited. The musculoskeletal implications of more subtle elastic fiber abnormalities, whether due to allelic variants or age-related tissue degeneration, are also not well understood. Recent advances have begun to uncover the effects of elastic fiber deficiency on tendon and ligament biomechanics; future research must further elucidate mechanisms governing the role of elastic fibers in these tissues. The identification of population-based genetic variations in elastic fibers will also be essential. Minoxidil administration, modulation of protein expression with micro-RNA molecules, and direct injection of recombinant elastic fiber precursors have demonstrated promise for therapeutic intervention, but further work is required prior to consideration for orthopedic clinical application. This review provides an overview of the role of elastic fibers in musculoskeletal tissue, summarizes current knowledge of the orthopedic manifestations of elastic fiber abnormalities, and identifies opportunities for future investigation and clinical application.

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Elastin peptides in aging and pathological conditions

Cited by 30 publications

References 117 publications

The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity

The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity

The effect of mangiferin on skin: Penetration, permeation and inhibition of ECM enzymes

Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions

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