Elastometry Indices of Unchanged Liver in Healthy Children

Пыков, М. И.; Kuzmina, Natalia; Rostovtsev, N. M.; Kinzersky, Alexander

doi:10.5772/intechopen.88004

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…In clinical practice, this factor seems to be especially relevant for individual follow-up of patients, which should be performed with a similar setup as the baseline examination to reduce spurious variability in results. A slight age dependency of liver elasticity has been shown using VCTE (3.4 kPa in ages 1–5 years to 4.1 kPa in ages 12–18 years) [ 79 ] and 2-D SWE (4.9 kPA in ages 3–6 years and 5.2 kPa in ages 12–18 years [ 80 ]. A study including 128 healthy children showed that height was the only significant predictor of shear wave speed (positively correlated) [ 74 ].…”

Section: Liver Stiffnessmentioning

confidence: 99%

Liver cirrhosis in children – the role of imaging in the diagnostic pathway

Herrmann

Petit

Grabhorn³

et al. 2022

Pediatr Radiol

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Liver cirrhosis in children is a rare disease with multifactorial causes that are distinct from those in adults. Underlying reasons include cholestatic, viral, autoimmune, hereditary, metabolic and cardiac disorders. Early detection of fibrosis is important as clinical stabilization or even reversal of fibrosis can be achieved in some disorders with adequate treatment. This article focuses on the longitudinal evaluation of children with chronic liver disease with noninvasive imaging tools, which play an important role in detecting cirrhosis, defining underlying causes, grading fibrosis and monitoring patients during follow-up. Ultrasound is the primary imaging modality and it is used in a multiparametric fashion. Magnetic resonance imaging and computed tomography are usually applied second line for refined tissue characterization, clarification of nodular lesions and full delineation of abdominal vessels, including portosystemic communications.

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Section: Liver Stiffnessmentioning

confidence: 99%

Liver cirrhosis in children – the role of imaging in the diagnostic pathway

Herrmann

Petit

Grabhorn³

et al. 2022

Pediatr Radiol

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Thyroid Elastography in Children

Пыков¹,

Kuzmina

Rostovtsev

2022

Acta med. Eurasica

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The aim of the research was to study the stiffness of an unchanged thyroid gland using shear wave elastography with elastometry in children in different gender and age groups. 175 children with normal hormonal status aged from 3 to 17 were examined, 80 of them were girls and 95 boys. All children underwent ultrasound examination of the thyroid gland in the "supine" position of the examinees, supplemented by two-dimensional shear wave elastography on Aixplorer apparatus (Supersonic Imagine, France) using a linear sensor in the frequency range of 5-18 MHz. Five measurements of Young's modulus value of the right and left lobes of the thyroid gland were carried out. Using Multi Q-box software, the following values of Young's modulus (E) for each fraction were automatically determined: the mean (Emean), the maximum (Emax), the minimum (Emin), the standard deviation (SD). The study established a statistically significant increase in thyroid stiffness values in children with increasing age, statistically significant differences in the stiffness of thyroid right and left lobes (p = 0.003), the absence of gender differences in thyroid stiffness (median Emean in boys – 7.40 kPa, in girls – 6.80 kPa; p = 0.170). The technique of shear wave elastography that is offered by the authors can become an additional diagnostic tool in assessing the condition of the thyroid gland in children. The established values of thyroid tissue stiffness in children of different age groups can be recommended to be used for the purpose of timely diagnosis of thyroid pathology.

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Shear Wave Elastography in the Assessment of Liver Changes in Children with Cystic Fibrosis

Пыков¹,

Kuzmina²,

Rostovtsev³

2022

Elastography - Applications in Clinical Medicine

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A standard ultrasound examination of the liver was performed in 232 children. It was supplemented by a two-dimensional shear wave elastography. There were 200 healthy children aged 3 to 18 years (control group) and 32 patients with cystic fibrosis aged 2 to 17 years (study group) among them. The procedure was carried out by means of Aixplorer device (Supersonic Imagine, France) using a convex sensor operating in the 1–6 MHz frequency range. Ten measurements of Young modulus values were carried out in different segments of the right lobe of the liver followed by data averaging. In patients with cystic fibrosis, the values of Young modulus were significantly higher than in healthy children (Emean median: 6.50 and 5.00 kPa, interquartile range: 5.62–7.52 and 4.70–5.38 kPa, respectively (p < 0.001). In patients with severe cystic fibrosis, the values of Young modulus were significantly higher compared to patients suffering from moderate disease (Emean median: 7.30 and 5.90 kPa, interquartile range: 6.20–10.70 and 5.20–6.75 kPa, respectively (p < 0.002). Shear wave elastography is a non-invasive technique that can be successfully used in a comprehensive ultrasound assessment of the liver in children with cystic fibrosis to facilitate the diagnosis and monitoring of fibrous changes.

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Elastometry Indices of Unchanged Liver in Healthy Children

Cited by 3 publications

References 13 publications

Liver cirrhosis in children – the role of imaging in the diagnostic pathway

Liver cirrhosis in children – the role of imaging in the diagnostic pathway

Thyroid Elastography in Children

Shear Wave Elastography in the Assessment of Liver Changes in Children with Cystic Fibrosis

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