Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome

Namakin, Kosar; Moghaddam, Meysam Hassani; Sadeghzadeh, Sara; Mehranpour, Maryam; Vakili, Kimia; Fathi, Mobina; Golshan, Ahmadreza; Bayat, Amir‐Hossein; Tajik, Amir-Hossein; Eskandari, Neda; Mohammadzadeh, Ibrahim; Benisi, Soheila Zamanlui; Aliaghaei, Abbas; Abdollahifar, Mohammad‐Amin

doi:10.1007/s11011-023-01187-6

Cited by 6 publications

(5 citation statements)

References 102 publications

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“…[ 94,95 ] The toxicity of GO NPs has been fully confirmed in various cases, including oxidative stress and lipid peroxidation. [ 10–87 ] As a proposed mechanism to justify these observations, it can be suggested that the EAFE, due to its antioxidant properties, can neutralize free radicals caused by GO NPs and it has the ability to maintain oxidative homeostasis and combat oxidative stress in kidney, lung and testis tissues of mice. [ 96 ] Patlolla et al.…”

Section: Discussionmentioning

confidence: 99%

“…The medicinal properties of elderberries are reportedly attributable mostly to their high content of polyphenols, including anthocyanins and flavonols. [86] Abd-Alsahib and Faris in (2022) stated that GO NPs with a concentration of 60 mg/kg/bw caused damages such as dilation of liver sinuses, proliferation of the nucleus of liver cells, thickening of the nucleus in some liver cells, penetration Inflammatory cells, bleeding and dissolution of hepatocytes in mice liver tissue. [10] Rhazouani et al ( 2023) stated that GO NPs cause inflammation in liver cells.…”

Section: Liver Histological Damagementioning

confidence: 99%

“…[123] Namakin et al (2023) stated that a diet containing elderberry can improve neurological disorders and inflammations in mice due to the presence of phenolic compounds. [86] Osman et al (2023) stated that elderberry has the ability to reduce oxidative stress due to its high polyphenolic compounds and strengthens the body's immune system. [124]…”

Section: Lung Histological Damagementioning

confidence: 99%

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Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

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The aim of this study is to investigate the protective effects of Elaeagnus angustifolia fruit extract (EAFE) on hematology, biochemical parameters, liver enzymes and damage of different tissues of male mice exposed to graphene oxide nanoparticles (GO NPs). In this research, 48 mice were divided into six groups. Hematology parameters including red blood cells (RBC), white blood cells (WBC), hematocrit (Ht), and hemoglobin (Hb), biochemical parameters such as cholesterol, triglyceride, glucose, protein, albumin, creatinine and bilirubin, liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) and histological damage of liver, kidney, lung and testis of mice were investigated. The results show that GO NPs in both concentrations (30 and 60 mg/kg/bw) decrease the number of RBC compared to the control group (p < 0.05). EAFE has no effect on RBC count while EAFE in combination with both concentrations of 30 and 60 mg/kg/bw GO NPs significantly (p < 0.05) improves the RBC count of mice. Also, the results show that EAFE improves the number of WBC, Ht, Hb, and biochemical parameters of mice exposed to different concentrations of GO NPs. A series of morphological changes were observed in the RBC of rats exposed to 60 mg/kg/bw GO NPs, including Dacrocyte, Poikilocyte and Schistocyte, which EAFE can improve the morphological changes caused in RBC. A series of histological damages such as degeneration and dilatation in the central vein in liver tissue, thickening and inflammatory cell infiltration in the renal capsule, peribronchiolar inflammatory cell infiltration and congestion in peribronchiolar blood vessels in lung tissue and decrease in the height of the germinal epithelium and a decrease in the population of spermatozoid cells in spermatogenic cells were observed in the testis of mice exposed to 60 mg/kg/bw GO NPs. The results show that EAFE can improve the damage caused by GO NPs in the liver, kidney and lung tissues, while it has no effect on the damage in the mice testis tissue. Therefore, GO NPs cause damage in the blood and different tissues of mice, and the use of EAFE can be effective in improving these damages.

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Section: Discussionmentioning

confidence: 99%

Section: Liver Histological Damagementioning

confidence: 99%

Section: Lung Histological Damagementioning

confidence: 99%

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Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

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“…The findings showed that the elderberry diet improved locomotion and decreased anxiety-like behavior in the rat models of IBS. 12 Moldovan et al, synthesized silver nano-particles using European black elderberry (Sambucus nigra) fruit extract via the green method. The results indicated that, fabricated nano-particles not only have a promising antioxidant capacity but also have a great potential in the development of therapeutic agents against oxidative tissue injuries.…”

Section: Introductionmentioning

confidence: 99%

“…The gut and brain tissues of the rats were investigated using histological, behavioral, and stereological techniques after 8 weeks of supplementation. The findings showed that the elderberry diet improved locomotion and decreased anxiety‐like behavior in the rat models of IBS 12 . Moldovan et al, synthesized silver nano‐particles using European black elderberry ( Sambucus nigra ) fruit extract via the green method.…”

Section: Introductionmentioning

confidence: 99%

Elderberry (Sambucus nigra) and hawthorn (Crataegus oxyacantha) extract additives in carboxymethyl chitosan scaffolds for osteochondral tissue engineering applications

Baysan,

Yilmaz,

Husemoglu

et al. 2024

J of Applied Polymer Sci

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Advancements in new treatment methods are becoming increasingly necessary due to a longer life expectancy, particularly in the field of osteochondral tissue engineering. In the present study, osteochondral tissue scaffolds with/without the addition of hawthorn or elderberry extracts were fabricated. Poly(ethylene glycol) diglycidyl ether (PEGDE) cross‐linked carboxymethyl chitosan hydrogel scaffold matrix was used as a control group. The addition of the plant extracts resulted in open porous structures with pore sizes around 100–450 μm and elastic modulus between 0.5 and 0.7 MPa, biomimicking the osteochondral tissue. Scaffolds containing either plant extract showed a high swelling tendency (1500–1750%) and a delayed release of the extracts after a week. Furthermore, the weight loss of the scaffolds after an enzymatic degradation for 56 days was ~30%. In addition, in vitro biocompatibility analyses were performed using bone marrow‐derived mesenchymal stem cells confirming non‐cytotoxicity for all the scaffold types. Biochemical assessment of alkaline phosphatase activity and glycosaminoglycan content yielded results consistent with osteochondral scaffold requirements. Finally, immunohistochemical analyses indicated that the plant extract addition, especially elderberry, increased collagen type I and type II formation. As a result, the addition of both hawthorn and elderberry extracts is a promising approach to osteochondral tissue regeneration.

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A systematic review of preclinical studies targeted toward the management of co-existing functional gastrointestinal disorders, stress, and gut dysbiosis

Pal,

Arisha,

Mazumder

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome

Cited by 6 publications

References 102 publications

Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Elderberry (Sambucus nigra) and hawthorn (Crataegus oxyacantha) extract additives in carboxymethyl chitosan scaffolds for osteochondral tissue engineering applications

A systematic review of preclinical studies targeted toward the management of co-existing functional gastrointestinal disorders, stress, and gut dysbiosis

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