Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates

Criniti, Amy; Thyer, Angela; Chow, Gregory E.; Lin, Paul; Klein, Nathan; Soules, Michael R.

doi:10.1016/j.fertnstert.2005.06.035

Cited by 94 publications

(69 citation statements)

References 30 publications

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“…Recent studies had focused on single blastocyst stage transfer in which the embryos were cultured to day 5 enhanced the likelihood of pregnancy compared to day 3 embryo transfer without the complications of multiple pregnancies [12]. It had been shown by another retrospective study that SBT demonstrated a noticeably decrease in twinning in comparison with the double blastocyst group (3 % VS 62 %) and still kept their pregnancy rates at 76 % and 79 %, for donor and non-donor IVF patients, respectively [7].…”

Section: Introductionmentioning

confidence: 99%

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

Zhao

Liu

et al. 2014

J Assist Reprod Genet

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Purpose To compare the clinical outcomes after day 3 embryo transfer, day 5 single blastocyst transfer (SBT) and frozenthawed embryo transfer (FET) in high responder patients (>15 retrieved oocytes) undergoing IVF/ICSI treatment. Methods A retrospective analysis of three embryo transfer strategies for the high responder patients in IVF/ICSI cycles. The 1041 high responder patients diagnosed as primary infertility with more than 15 oocytes retrieved were recruited in Day 3 ET group, 308 patients with more than 15 oocytes retrieved first transferred with one blastocyst in SBT group and 425 patients with more than 15 oocytes retrieved in fresh cycle, first transferred with one frozen-thawed blastocyst were assigned in FET group. Results In the high responder patients, the clinical pregnancy rate after day 5 SBT was significantly lower than that of day 3 ET (43.18 % VS 57.16 %, p <0.05). In addition, the clinical pregnant rate and implantation rate of FET cycles were significantly higher than SBT cycles (59.06 % vs. 43.18 % and 64.70 % vs. 47.40 %, p <0.05). The multiple pregnancy rate in FET cycles was markedly lower than that of day 3 ET (2.35 % VS 34.97 %, p <0.05).Conclusions FET was the preferable strategy for the high responder patients in IVF/ICSI cycles to obtain both desirable clinical outcome and lower multiple pregnancy rates.

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Section: Introductionmentioning

confidence: 99%

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

Zhao

Liu

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…A similar outcome was achieved when transferring a single blastocyst, compared to two blastocysts, 22 although higher pregnancy rates (positive pregnancy test, i.e. hCG) (OR 1.45, 95% CI 1.03-2.04) ( Figure 8) and clinical pregnancy rates (heartbeat present on ultrasound scan) (OR 1.63, 95% CI 1.12-2.35) ( Figure 9) were observed with single blastocyst transfer compared with day 3 eSET in women under 36 years of age.…”

Section: 21mentioning

confidence: 57%

Elective single embryo transfer

Kosmas

Elst

Devroey

et al. 2008

The Obstetric & Gynaecologis

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Elective single embryo transfer has been implemented in Belgium and Scandinavian countries to decrease the incidence of twin pregnancy and the associated complications. The extra cost associated with achieving an equal number of pregnancies through elective single embryo transfer needs to be considered in the context of any additional neonatal care expenses associated with double embryo transfer. Acceptable ongoing pregnancy and delivery rates have been obtained when comparing single with double embryo transfer. Maternal age, previous attempts, day of embryo transfer and cost should be taken into account. Learning objectives: To understand the issues raised when helping a couple choose single or double embryo transfer. Ethical issues: Where does patient autonomy over treatment end and national regulation begin? The management of obstetric complications and the long‐term sequelae of premature birth should be factored in when considering treatment costs. Please cite this article as: Kosmas I, Van der Elst J, Devroey P, Tournaye H. Elective single embryo transfer. The Obstetrician & Gynaecologist 2008;10:163–169.

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“…Elective single blastocyst embryo transfer has been shown to have equivalent implantation and pregnancy rates compared to double embryo transfer while significantly reducing the rate of twin gestations [16]. Emerging technology like preimplantation genetic screening (PGS) is used to select a single euploid embryo for transfer, therefore, improving pregnancy rates and decreasing the miscarriage rate due to aneuploidy [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

A comparison of pregnancy outcomes between day 3 and day 5/6 embryo transfers: does day of embryo transfer really make a difference?

Maxwell

Melzer-Ross²,

McCulloh

et al. 2015

J Assist Reprod Genet

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Purpose To determine if day of embryo transfer (ET) affects gestational age (GA) and/or birth weight (BW) at a single university fertility center that primarily performs day 5/6 ET. Methods Retrospective cohort study of 2392 singleton live births resulting from IVF/ICSI at a single large university fertility center from 2003 to 2012. Patients were stratified by day 3 or day 5/6 ET. Outcome variables included patient age, gravidity, prior miscarriages, prior assisted reproduction technology cycles, number of embryos transferred, number of single ET, infertility diagnosis, neonatal sex, GA at birth, and BW. Subanalyses were performed on subgroups of preterm infants. A comparison was made between the study data and the Society of Assisted Reproductive Technologies (SART) published data. Results There was no difference in GA at birth (39±2.1 weeks for day 3 ET, 39±1.9 weeks for day 5/6 ET) or BW between ET groups (3308±568 g for day 3 ET, 3268±543 g for day 5/6 ET). There was also no difference in the number of preterm deliveries (8.5 % for day 3 ET vs. 10.8 % for day 5/6 ET). The day 5/6 ET study data had significantly fewer pre-term deliveries than the SART day 5/6 ET data. Conclusion In contrast to published SART data, GA and BW were not influenced by day of ET. Data may be more uniform at a single institution. Day 5/6 ET continues to offer improved pregnancy rates without compromising birth outcomes.

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Elective single blastocyst transfer reduces twin rates without compromising pregnancy rates

Cited by 94 publications

References 30 publications

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?

Elective single embryo transfer

A comparison of pregnancy outcomes between day 3 and day 5/6 embryo transfers: does day of embryo transfer really make a difference?

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