Electric Field: A Key Signal in Wound Healing

Jia, Naixin; Yang, Jinrui; Liu, Jie; Zhang, Jiaping

doi:10.1016/s2096-6911(21)00090-x

Cited by 27 publications

(15 citation statements)

References 57 publications

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“…The internal electric field created by differences in the transepithelial potential plays a crucial part in the repair and renewal of wound surfaces, known as re-epithelialization. Since the first measurement of wound current by Emil Du-Bois Reymond over a century ago, successive research has verified that this internal electric field is present in a range of animals, and electrical therapy might effectively achieve synergistic wound healing by reshaping or intervening in the electric field. , It is vital for epithelialization, as it directs the movement of key electroactive cells, like epithelial cells, during wound repair. TENGs have been highlighted as innovative energy supply systems with low power and flexibility in the form of wearable or implantable medical devices to address the poor portability of conventional bulky electrotherapy equipment and power sources .…”

Section: Biomedical Applications Of B-tengsmentioning

confidence: 99%

Advances in Bioresorbable Triboelectric Nanogenerators

Kang,

Lee,

Hyun

et al. 2023

Chem. Rev.

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With the growing demand for next-generation health care, the integration of electronic components into implantable medical devices (IMDs) has become a vital factor in achieving sophisticated healthcare functionalities such as electrophysiological monitoring and electroceuticals worldwide. However, these devices confront technological challenges concerning a noninvasive power supply and biosafe device removal. Addressing these challenges is crucial to ensure continuous operation and patient comfort and minimize the physical and economic burden on the patient and the healthcare system. This Review highlights the promising capabilities of bioresorbable triboelectric nanogenerators (B-TENGs) as temporary self-clearing power sources and self-powered IMDs. First, we present an overview of and progress in bioresorbable triboelectric energy harvesting devices, focusing on their working principles, materials development, and biodegradation mechanisms. Next, we examine the current state of on-demand transient implants and their biomedical applications. Finally, we address the current challenges and future perspectives of B-TENGs, aimed at expanding their technological scope and developing innovative solutions. This Review discusses advancements in materials science, chemistry, and microfabrication that can advance the scope of energy solutions available for IMDs. These innovations can potentially change the current health paradigm, contribute to enhanced longevity, and reshape the healthcare landscape soon.

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Section: Biomedical Applications Of B-tengsmentioning

confidence: 99%

Advances in Bioresorbable Triboelectric Nanogenerators

Kang,

Lee,

Hyun

et al. 2023

Chem. Rev.

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show abstract

“…Wound healing is a complex biological process with four classified stages of wound states appearing in order: Hemostasis, Inflammatory, Proliferative, and Remodeling. [92][93][94] In the meantime, the alternating electrical field stimulation by TENG imitates an endogenous electric field's natural wound-healing mechanism to facilitate skin growth. Briefly, the endogenous electric field is caused by the leakage of ions such as Na + , Cl + , K + , and Ca 2+ from the injured cell or cell layer.…”

Section: Mechanism Of the Wound Healing Tengmentioning

confidence: 99%

Smart Triboelectric Nanogenerators Toward Human‐Oriented Technologies: Health Monitoring, Wound Healing, Drug Delivery

Yum

Han

Konstantinov

et al. 2023

Adv Materials Technologies

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Advanced biotechnologies applying electricity to the human body have been studied and developed for a long time since their first invention, but these technologies still have explicit limitations that block their practical application to humans. In these circumstances, the triboelectric nanogenerator (TENG) has emerged as a breakthrough in the biotechnology field with its intrinsic advantages. In this review, an overview of the current development of TENGs for human‐oriented technologies is provided. The review starts with a brief explanation of the TENG mechanism and presents detailed reasons why it has become a focal point in these fields. Then, there are clear explanations of the TENG applicable mechanism in the field of health monitoring, wound healing, and drug delivery. After each explanation, related research and materials are covered in full detail, and all relevant research information is listed in the table. Finally, challenges and perspectives will be discussed for each part's future studies.

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“…Remarkably similar and steady endogenous EFs to those present in the amphibian blastema were also identified in the blastema of the amputated digit of human children ( Illingworth and Barker, 1980 ). Known as the injury potential, or demarcation current, a difference in electrical potential is created between intact epithelium and the site of a wound ( Jia et al, 2021 ). The TEPD at the site of injury falls and current “leaks” out from the wound edge, being the pathway of least resistance, creating an electrical field ( Figure 2C ).…”

Section: Biological Electrical Fields In Vivo : Th...mentioning

confidence: 99%

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

O’Hara-Wright

Mobini

Gonzalez‐Cordero

2022

Front. Cell Dev. Biol.

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Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in in vitro tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of in vivo developmental cues, including biochemical and biomechanical. However, a lesser studied cue, bioelectricity, has been shown to regulate central nervous system development and function. In particular, electrical stimulation of neural cells has generated some important phenotypes relating to development and differentiation. Emerging techniques in bioengineering and biomaterials utilise electrical stimulation using conductive polymers. However, state-of-the-art pluripotent stem cell technology has not yet merged with this exciting area of bioelectricity. Here, we discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilised as a novel technique to engineer “next-generation” organoids.

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Electric Field: A Key Signal in Wound Healing

Cited by 27 publications

References 57 publications

Advances in Bioresorbable Triboelectric Nanogenerators

Advances in Bioresorbable Triboelectric Nanogenerators

Smart Triboelectric Nanogenerators Toward Human‐Oriented Technologies: Health Monitoring, Wound Healing, Drug Delivery

Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

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