Electrical activity of sensory pathways in female and male geriatric Rhesus monkeys ( Macaca mulatta ), and its relation to oxidative stress

Effect of age on electrical nerve conduction in the somatosensory pathway and its correlation with somatometry and plasma concentrations of musculoskeletal enzymes in male rhesus monkeys (Macaca mulatta) held in captivity

“…Moreover, a common factor that has been related to decreased neuronal excitability, and reduced electrophysiological activity in the nervous system (NS), along with increased brain damage, is oxidative stress. 47,48 In this context, Ibáñez-Contreras et al 48 revealed that lipoperoxidation (LPX) increased during aging in rhesus monkeys, and also correlated the increase of the LPX with latency delay in all sensory pathways.…”

“…Based on these findings, it appears that the degradation or destruction of myelin affects the nerve fibers and, therefore, the nerves' ability to conduct electrical impulses to and from the brain. 10,32,[46][47][48][49][50] An additional observation was the strong relation between the lengths evaluated and the appearance of the absolute latencies of the different neural generators in the somatosensory pathway, regardless of age group (Figure 5A,B). This phenomenon has been described widely in humans.…”

“…They further describe the possibility that the combination of age in relation to the development of alterations of the PNS and CNS may drastically affect processing of somatosensory information. Moreover, a common factor that has been related to decreased neuronal excitability, and reduced electrophysiological activity in the nervous system (NS), along with increased brain damage, is oxidative stress . In this context, Ibáñez‐Contreras et al revealed that lipoperoxidation (LPX) increased during aging in rhesus monkeys, and also correlated the increase of the LPX with latency delay in all sensory pathways.…”

“…Moreover, a common factor that has been related to decreased neuronal excitability, and reduced electrophysiological activity in the nervous system (NS), along with increased brain damage, is oxidative stress . In this context, Ibáñez‐Contreras et al revealed that lipoperoxidation (LPX) increased during aging in rhesus monkeys, and also correlated the increase of the LPX with latency delay in all sensory pathways. The correlation analysis showed in this work supporting the idea that the oxidative damage generated in the central nervous system (CNS) and peripheral nervous system (PNS) is associated with a decreased excitability and electrophysiological activity during aging in rhesus monkeys.…”

Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?

“…In animals, older male rhesus macaques with low T levels have elevated blood oxidative stress biomarkers and older females with low estradiol (E2) levels exhibit similar effects (Ibáñez-Contreras et al, 2018). Orchidectomy lowers and elevates serum and testicular antioxidant and oxidative stress levels in rat, respectively (Deyhim et al, 2006(Deyhim et al, , 2007Bae et al, 2017); it increases brain and serum oxidative stress in rats (Pintana et al, 2015;Meydan et al, 2010); and it can be attenuated by daily low dose (0.5 mg/kg, SC) T administration (Meydan et al, 2010).…”