Electrical and Physical Methods of Skin Penetration Enhancement

Grice, Jeffrey E.; Prow, Tarl W.; Kendall, M. A. F.; Roberts, Michael S.

doi:10.1002/9781118140505.ch3

Cited by 5 publications

(2 citation statements)

References 126 publications

(123 reference statements)

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“…Different strategies for drug penetration enhancement can be used aiming to circumvent the SC barrier. Among them, occlusion, formulation optimization and physical methods can be used alone or combined (Grice et al, 2012). Physical methods can potentially increase the transport of macromolecules to the SC, enabling higher concentrations of drugs into deep skin layers (Gratieri et al, 2008).…”

Section: Physical Methods For Topical Drug Deliverymentioning

confidence: 99%

Physical methods for topical skin drug delivery: concepts and applications

Petrilli

Lopez

2018

Braz. J. Pharm. Sci.

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Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic. In this context, different physical methods have been studied to overcome the stratum corneum barrier and facilitate penetration of drugs into or through the skin. Among them, iontophoresis, low-frequency ultrasound and microneedles have been widely employed for transdermal drug delivery. More recently, they are also studied to aid in the treatment of dermatological disorders, such as skin tumors and inflammation. Basically, iontophoresis refers to the movement of charged and non-charged hydrophilic molecules through the skin due to the application of a low constant electric current and the contributions of electromigration and electroosmosis. In low-frequency ultrasound, cavitation is the main mechanism for skin permeabilization that consists on the formation of microbubbles that disorganize the stratum corneum. Microneedles are microprojections, minimally invasive, that can be designed with different lengths, materials and geometry to increase skin permeability. In this review, concepts, mechanisms and applications of these three physical methods will be presented and discussed with focus on their use in dermatological treatments. Moreover, comparative studies using different physical methods will be presented and also some clinical perspectives will be addressed.

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Section: Physical Methods For Topical Drug Deliverymentioning

confidence: 99%

Physical methods for topical skin drug delivery: concepts and applications

Petrilli

Lopez

2018

Braz. J. Pharm. Sci.

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“…In efforts to extend the range of potential skin deliverables, various active technologies that apply physical forces to overcome the skin barrier, utilizing acoustic, electrical, or electromagnetic energy (e.g. laser radiation or radiofrequencies) and high pressure have been extensively investigated over several decades [185,186]. Techniques include iontophoresis, sonophoresis, thermal and radiofrequency ablation, laser assisted delivery and jet propulsion systems, as well as microneedles, which directly breach the stratum corneum.…”

Section: Physical Enhancement and Combinational Methods For Facilitatmentioning

confidence: 99%

Topical and cutaneous delivery using nanosystems

Roberts

Mohammed

Pastore

et al. 2017

Journal of Controlled Release

222

118

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The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review.

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Vesicular Nanocarriers: A Potential Platform for Dermal and Transdermal Drug Delivery

Kassem

El-Alim

2020

Nanopharmaceuticals: Principles and Applications Vol. 2

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Electrical and Physical Methods of Skin Penetration Enhancement

Cited by 5 publications

References 126 publications

Physical methods for topical skin drug delivery: concepts and applications

Physical methods for topical skin drug delivery: concepts and applications

Topical and cutaneous delivery using nanosystems

Vesicular Nanocarriers: A Potential Platform for Dermal and Transdermal Drug Delivery

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