Electrical based cancer therapy for solid tumours - Theranostics approach

Iyer, Mahalaxmi; Venugopal, Anila; Chandrasekhar, Mamatha; Suriyanarayanan, Atchaya; Balasubramani, Kiruthika; Ilangovan, Anand Sinthai; Kamalakannan, S.; Gunaseelan, Rupa; Ayyadurai, Niraikulam; Gopalakrishnan, Abilash Valsala; Balraj, Lohita Rachaiah; Aghil, Immanuel; Palanisamy, Sivaprakash; Vellingiri, Balachandar; Narayanasamy, Arul

doi:10.1016/j.biosx.2022.100214

Cited by 2 publications

(3 citation statements)

References 112 publications

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“…-Support chemotherapy, drug-free and nonthermal therapy could be combined with immunotherapy (Iyer et al, 2022).…”

Section: Electro-capacitive Cancer Therapymentioning

confidence: 99%

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The Specificity and Efficacy of Alternating Electric Fields as a Prospective Cancer Treatment

Palupi,

Retnoaji,

Astuti

et al. 2023

ASMScJ

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An external electric field is still debatable for cancer treatment, although many study results proved its capacity. Cancer involves complex mechanisms, including how the cancer cells arise and grow. Thus, this disease is known to have many hallmarks. This condition complicates precise and accurate treatment. The study proved that an external electric field has prospects to become an effective cancer treatment, demonstrated by its ability to inhibit cancer growth through anti-proliferative and pro-apoptotic capacities. Several devices generating electric fields for cancer treatment were Tumour Treating Fields (TTFields), nanosecond Pulsed Electric Fields (nsPEF), picosecond Pulsed Electric Fields (psPEF), and Electro-Capacitive Cancer Therapy (ECCT). This article will compare those devices’ efficacy, safety, treatment methods, and research progress, including the advantages and disadvantages of static electric field devices and future research prospects. More attention will be focused on ECCT, which has been closely and profoundly investigated in breast cancer treatment.

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“…-Support chemotherapy, drug-free and nonthermal therapy could be combined with immunotherapy (Iyer et al, 2022).…”

Section: Electro-capacitive Cancer Therapymentioning

confidence: 99%

“…-Inducing electrochemotherapy, modification of cell membrane permeability, and electroporation effect (Iyer et al, 2022).…”

Section: Electro-capacitive Cancer Therapymentioning

confidence: 99%

The Specificity and Efficacy of Alternating Electric Fields as a Prospective Cancer Treatment

Palupi,

Retnoaji,

Astuti

et al. 2023

ASMScJ

View full text Add to dashboard Cite

show abstract

“…[ 14 ] Further, EST, in combination with immunotherapy and chemotherapy, has demonstrated significant tumor reduction in cervical, ovarian and breast cancer in in vitro studies and in vivo animal models. [ 15 ]…”

Section: Introductionmentioning

confidence: 99%

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Jayasree,

Cartmell,

Ivanovski

et al. 2024

Adv Funct Materials

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Modulating cellular functions at the dental implant‐tissue interface to augment integration and prevent bacterial ingress is crucial for achieving early stability and long‐term implant success. Nano‐engineering strategies, such as anodized titanium implants with titania (TiO2) nanotubes/nanopores, are emerging as a promising dental implant surface modification approach to enhance integration and prevent infection. Achieving on‐demand therapy through electrical stimulation therapy (EST, supply of voltage/current to local tissue) may be advantageous but has not been explored for dental implants. Further, anodized implants with TiO2 nanotubes/nanopores represent a semi‐conducting modification that can impede EST effectiveness. In this pioneering study, TiO2 nanopores are converted into conducting Ti nanopores to perform EST to achieve superior soft‐tissue integration and antibacterial efficacy. In‐depth surface characterizations are followed by assays investigating the effect of EST on cultured human salivary biofilm and gingival fibroblasts. Significant bactericidal efficacy is demonstrated for EST (1.5 V for 5 min per day) using Ti nanopores. Further, EST enhanced fibroblast proliferation and collagen secretion. In summary, EST applied to Ti nanoporous implants promotes soft‐tissue healing and antibacterial functions and is proposed as a next‐generation approach in implant dentistry to achieve on‐demand therapy.

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Electrical based cancer therapy for solid tumours - Theranostics approach

Cited by 2 publications

References 112 publications

The Specificity and Efficacy of Alternating Electric Fields as a Prospective Cancer Treatment

The Specificity and Efficacy of Alternating Electric Fields as a Prospective Cancer Treatment

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

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