Electrical impedance spectroscopy and the diagnostic accuracy for malignant melanoma

Åberg, Peter; Birgersson, Ulrik; Elsner, Peter; Mohr, Peter; Ollmar, Stig

doi:10.1111/j.1600-0625.2011.01285.x

Cited by 75 publications

(47 citation statements)

References 30 publications

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“…Recent studies have suggested that the impedance technique is capable of detecting precancerous lesions in a wide range of different tissues. Impedance technology has been shown to differentiate reliably between benign and malignant tissue in the prostate 9 and to be able to identify malignant melanoma, 10 cervical cancer, 11 and malignant tissue in the upper gastrointestinal tract. [12][13][14] In addition to several smaller pilot studies, there have been two larger studies investigating the impedance technique in malignant lesions.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14] In addition to several smaller pilot studies, there have been two larger studies investigating the impedance technique in malignant lesions. In a Europe-wide multicentre study, 10 183 patients underwent probe-based impedance spectroscopy for detection of malignant melanomas. The authors reported a sensitivity of 95% and specificity of 49% for the novel method.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Knabe¹,

Kurz

Knoll

et al. 2013

UEG Journal

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Background: Detection of early oesophageal cancer in surrounding normal tissue can be challenging, but detection is essential to determine the subsequent treatment. Dysplastic tissue can be detected by using electrical impedance spectroscopy (EIS). Objective: The aim of the present study was to evaluate the feasibility and value of EIS in the diagnosis of oesophageal neoplasia.Methods: This prospective ex-vivo study included 23 patients with early oesophageal cancer (17 with Barrett's cancer and six with early squamous cell cancer). Immediately after endoscopic resection, the electrical properties of the resected specimens were investigated using a pencil probe (5 mm in diameter, frequency range from 100 Hz to 1 MHz). Punch biopsies were taken from the measured site in order to compare the results of EIS with histology. Results: EIS was able to detect dysplastic oesophageal mucosa with a high rate of accuracy (82% in Barrett's oesophagus and 100% in squamous oesophagus) A total of 54 different sites in 26 tumours were evaluated. Conclusions: EIS was able to differentiate reliably between non-neoplastic and neoplastic oesophageal mucosa. Using EIS, it might be possible to use it for targeted biopsies and to avoid unnecessary biopsies during cancer surveillance in future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Knabe¹,

Kurz

Knoll

et al. 2013

UEG Journal

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“…Nevisense ® (SciBase AB, Stockholm, Sweden) is a diagnostic tool based on electrical impedance spectroscopy (EIS) [5–7]. It measures tissue resistance by administering alternating electrical currents at various frequencies to the skin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions

Ceder

Hylén

Larko

et al. 2016

Dermatol Pract Concept

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BackgroundEarly detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions.ObjectivesThe aim of this study was to assess whether EIS, in addition to ST-SDDM, could improve the selection of AMLs requiring surgery.MethodsIn this retrospective descriptive study, 22 AMLs in 19 patients were monitored with both ST-SDDM and EIS. A modified EIS decision-making algorithm was established. AMLs were excised if any dermoscopic changes were seen and/or if the EIS score had increased significantly at follow-up. Statistical analyses were made including sensitivity, specificity, PPV and NPV.ResultsA total of seven lesions (32%) were excised. Four lesions (57%) were excised solely because of dermoscopic changes including a 0.4 mm-thick melanoma and three benign nevi. Three benign lesions (43%) were excised because of increased EIS scores without any dermoscopic changes. The EIS scores at follow-up showed high variability as compared to the initial scores.ConclusionThe addition of EIS to ST-SDDM did not identify additional malignant lesions. There was no correlation between dermoscopic changes seen with ST-SDDM and increased EIS scores. Three histopathologically benign lesions were needlessly excised. Moreover, the low reproducibility and the possible interoperator variability of the method raised concerns.

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“…Infrared spectroscopy [34], Raman spectroscopy [35,36], thermographic imaging [37], tissue elastography [38], fiber diffraction [39], electric impedence spectroscopy [40,41], and noninvasive genomic detection [42] may all play a role in assisting with the diagnosis of melanoma in the future. Mobile smartphone apps also offer an opportunity for patients to monitor their own skin for suspicious lesions, but current apps have, thus far, been shown to be insufficiently accurate [43,44].…”

Section: Other Technologies On the Horizonmentioning

confidence: 99%

Point of care cutaneous imaging technology in melanoma screening and mole mapping

2014

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Melanoma is a malignancy of melanocytes or pigment-producing cells located predominantly in the skin. It is less common than other skin cancers but causes the greatest number of skin cancer-related deaths worldwide. The incidence of melanoma continues to increase and early detection is the most promising means of decreasing morbidity and mortality. Currently, physicians perform routine skin cancer screenings for melanoma without the benefit of imaging devices more advanced than handheld magnifiers or dermatoscopes. However, it is possible that the diagnosis of melanoma may be improved with technology that provides diagnostic discrimination beyond what is possible on routine inspection. This article reviews current and emerging technologies to aid in the diagnosis of melanoma. Ultimately, these advances may enhance the early diagnosis of melanoma.

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Electrical impedance spectroscopy and the diagnostic accuracy for malignant melanoma

Cited by 75 publications

References 30 publications

Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions

Point of care cutaneous imaging technology in melanoma screening and mole mapping

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