Electrical stimulation with non-implanted electrodes for overactive bladder in adults

Stewart, Fiona; Gameiro, Luís Felipe Orsi; Dib, Regina El; Gameiro, Mônica; Kapoor, Anil; Amaro, João Luiz

doi:10.1002/14651858.cd010098.pub4

Cited by 37 publications

(21 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…N. gonorrhoeae is a common cause of ophthalmia neonatorum or neonatal conjunctivitis acquired during delivery from an infected mother. If left untreated, it can lead to corneal perforation and blindness, with neonatal conjunctivitis being a major cause of childhood corneal blindness in developing countries 26 – 28 . With the increasing occurrence of multidrug-resistant strains of bacteria, an alternative treatment for N. gonorrhoeae is very valuable and these experiments show that Bald’s eyesalve has the potential to be developed into a viable alternative.…”

Section: Discussionmentioning

confidence: 99%

“…Key candidates for future testing could include diabetic foot ulcers with a treatment cost average of £7800 per infection annually in the UK 33 . Other potential treatment target include neonatal conjunctivitis, a major cause of childhood corneal blindness in developing countries 26 . Our results are very promising, and the next steps would be to perform rigorous topical testing on healthy humans to determine any potential irritation or toxicity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The safety profile of Bald’s eyesalve for the treatment of bacterial infections

Anonye

Nweke

Furner-Pardoe

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The rise in antimicrobial resistance has prompted the development of alternatives to combat bacterial infections. Bald’s eyesalve, a remedy used in the Early Medieval period, has previously been shown to have efficacy against Staphylococcus aureus in in vitro and in vivo models of chronic wounds. However, the safety profile of Bald’s eyesalve has not yet been demonstrated, and this is vital before testing in humans. Here, we determined the safety potential of Bald’s eyesalve using in vitro, ex vivo, and in vivo models representative of skin or eye infections. We also confirmed that Bald’s eyesalve is active against an important eye pathogen, Neisseria gonorrhoeae. Low levels of cytotoxicity were observed in eyesalve-treated cell lines representative of skin and immune cells. Results from a bovine corneal opacity and permeability test demonstrated slight irritation to the cornea that resolved within 10 min. The slug mucosal irritation assay revealed that a low level of mucus was secreted by slugs indicating moderate mucosal irritation. We obtained promising results from mouse wound closure experiments; no visible signs of irritation or inflammation were observed. Our results suggest that Bald’s eyesalve could be tested further on human volunteers to assess safety for topical application against bacterial infections.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The safety profile of Bald’s eyesalve for the treatment of bacterial infections

Anonye

Nweke

Furner-Pardoe

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Previous systematic reviews have combined percutaneous (needle-electrode) TNS and transcutaneous (surface electrode) TNS in the same review, 19,23,56 hence the current lack of clarity in our understanding of effectiveness, cost-effectiveness, and best position in the treatment algorithm for each intervention and the tendency to consider them as equivalent. This situation fails to recognize the potential to target each more carefully.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome: A systematic review

Booth

Connelly

Dickson

et al. 2017

Neurourology and Urodynamics

View full text Add to dashboard Cite

Limited evidence is provided that TTNS is an effective, safe intervention for idiopathic OAB in adults and may be of benefit in those with neurogenic OAB. Further studies are essential to confirm these results as well as to determine efficacy and associated costs for specific patient groups, most effective stimulation dosage, duration of effect, and stimulation regimes for longer-term maintenance.

show abstract

“…They concluded that ES shows promising results compared to no treatment, placebo/sham treatment, PMFT, and drug treatment and that adding ES to other treatments might be beneficial. 53 …”

Section: Resultsmentioning

confidence: 99%

Effectiveness of percutaneous tibial nerve stimulation in the treatment of overactive bladder syndrome

Wall¹,

Heesakkers²

2017

RRU

View full text Add to dashboard Cite

Overactive bladder syndrome (OAB) is a common condition affecting adults and children worldwide, resulting in a substantial economic and psychological burden. Percutaneous tibial nerve stimulation (PTNS) is derived from acupuncture used in Chinese traditional medicine and was first described in the early 1980s. It is a neuromodulation technique used to modulate bladder function and facilitate storage. Being a minimally invasive, easily applicable, but time-consuming treatment, future developments with implantable devices might be the solution for the logistical problems and economic burden associated with PTNS on the long term. This nonsystematic review provides a current overview on PTNS and its effectiveness in the treatment of OAB for both adults and children.

show abstract

Electrical stimulation with non-implanted electrodes for overactive bladder in adults

Abstract: Analysis 5.1. Comparison 5 Electrical stimulation (ES) versus drug therapy, Outcome 1 Number of participants cured. Analysis 5.2. Comparison 5 Electrical stimulation (ES) versus drug therapy, Outcome 2 Number of participants cured or

Cited by 37 publications

References 139 publications

The safety profile of Bald’s eyesalve for the treatment of bacterial infections

The safety profile of Bald’s eyesalve for the treatment of bacterial infections

The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome: A systematic review

Effectiveness of percutaneous tibial nerve stimulation in the treatment of overactive bladder syndrome

Contact Info

Product

Resources

About