Electrifying Organic Synthesis

Abstract

The direct synthetic organic use of electricity is currently experiencing a renaissance. More synthetically oriented laboratories working in this area are exploiting both novel and more traditional concepts, paving the way to broader applications of this niche technology. As only electrons serve as reagents, the generation of reagent waste is efficiently avoided. Moreover, stoichiometric reagents can be regenerated and allow a transformation to be conducted in an electrocatalytic fashion. However, the application of electroorganic transformations is more than minimizing the waste footprint, it rather gives rise to inherently safe processes, reduces the number of steps of many syntheses, allows for milder reaction conditions, provides alternative means to access desired structural entities, and creates intellectual property (IP) space. When the electricity originates from renewable resources, this surplus might be directly employed as a terminal oxidizing or reducing agent, providing an ultra‐sustainable and therefore highly attractive technique. This Review surveys recent developments in electrochemical synthesis that will influence the future of this area.

Hochkonversion von Reduktionsmitteln

“…[63] Mehr und mehr erweitert die Elektrochemie ihren Einfluss auf die Synthesechemie,w os ie oft konzeptionell neue Wege bietet, Reaktionskaskaden mit hoher Selektivität, hervorragender Atomçkonomie und minimaler Abfallmenge zu entwerfen. [64] In diesem Aufsatz haben wir gezeigt, wie das Reduktionspotential durch die Nutzung der Gibbs-Energie exergonischer Reaktionen gesteigert ("hochkonvertiert") werden kann. [65] Wirhaben die grundlegenden Eigenschaften solcher Prozesse skizziert und bieten zwei mçgliche Designs von funktionsfähigen reduktiven Hochkonvertern an:u nimolekular/dissoziativ und bimolekular/assoziativ.…”

Trimethyl Lock: A Multifunctional Molecular Tool for Drug Delivery, Cellular Imaging, and Stimuli‐Responsive Materials

“…Photocleavablepolymer based on photosensitive sulfide-substituted quinone-type TML moieties. Electrochemically triggered TML systems Considering the recentr ise of organic electrochemistry, [221,222] it should be noted that quinone-type TML moieties can be electrochemically triggeredf or lactonization under mild conditions. [218].…”

Melt Spin Coating for X‐Ray‐Sensitive Hybrid Organic–Inorganic Layers of Small Carbazolyl‐Containing Molecules Blended with Tungsten

“…In the context of modern chemistry, the variety of organic materials is significantly increased by the new methods of synthesis. The new chemical compounds with simpler synthesis and improved electrical and mechanical properties are the key materials for prospective functional applications . Meanwhile, not only do organic applications help to improve conventional electronic devices but also the widespread crystal compounds are increasingly involved in the development of flexible electronics.…”