Electro-gene therapy in a human oral tongue cancer cell by intratumoral injection of pcDNA3.1-p27^Kip1 wt

8-Hydroxycudraxanthone G Suppresses IL-8 Production in SP-C1 Tongue Cancer Cells

“…Chromatographic procedures on this fraction yielded nine known compounds, which were identified by NMR spectroscopy and by comparison with published data as γ-mangostin (1) [12], α-mangostin (2) [12], β-mangostin (3) [13], 8-hydroxycudraxanthone G (4) [14], cudraxanthone G (5) [15], garcinone D (6) [16], mangostanin (7) [17], garcinone C (8) [18], and 1-mangostanin (9) [19]. xanthones IC 50 (µg/mL) -Mangostin 1352.1 α-Mangostin 214.4 -Mangostin 3291.4 8-Hydroxycudraxanthone G (4) 64.0 Cudraxanthone G (5) 36.9 Garcinone D (6) 72.4 Mangostanin 7335.1 Garcinone C (8) 76.0 1-Isomangostanin 9146.7…”

“…Angiogenesis is considered as an effective therapeutic strategy related to metastasis in the primary tumor that will not duplicate itself until new blood vessels are available. Angiogenesis inhibition has the potential of inhibiting tumor growth, as well as stopping the spread to other parts of the human body [8]. Figure 1 shows the suppression of IL-8 production by 8-hydroxycudraxanthone G (4) over 48 hours of testing.…”

“…The original SP-C1 cells were a moderately differentiated squamous cell carcinoma of the tongue, and were not invasive into the muscle layer. SP-C1 cell cultures are characterized by rapid growth, and high invasion and metastasis ability, because the cells come from a phenotypic refractory carcinoma of the tongue, recurrence of which is very high, despite radical surgery and the mean duration of survival is short [8,9]. The in vitro characteristics of SP-C1 cells make them an ideal model for studying apoptosis and angiogenesis [10].…”

Design and evaluation of an affordable and programmable mobile device, capable of delivering constant current and high voltage electric pulses of different waveforms for biomedical and clinical applications

“…The application of electroporation technique in biotechnology, bioengineering, biomedicine and clinical settings had created surge of interest not only for cancer treatments [2][3][4][5]: such as head and neck cancer [6], endometrial cancer [7], lung tumors [8], pancreatic cancer [9], and other cancer [10]; but also gene therapy [11], drug delivery [12][13][14][15][16], transcutaneous sampling of molecules [18,19,[45][46][47][48][49], such as glucose [17].…”