Electro-sensing base for mefenamic acid on a 5% barium-doped zinc oxide nanoparticle modified electrode and its analytical application

Bukkitgar, Shikandar D.; Shetti, Nagaraj P.; Kulkarni, Raviraj M.; Nandibewoor, Sharanappa T.

doi:10.1039/c5ra22581g

Cited by 79 publications

(27 citation statements)

References 64 publications

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“…The relationship between I p versus square root of the scan rate (υ 1/2 /(mV s −1 ) 1/2 ) was nonlinear indicating an adsorptive process as well. Likewise the relationship between logarithm of peak current (log I p /μA) versus logarithm of scan rate (log υ/Vs −1 ) also suggest that the process was adsorption‐controlled, since the slopes to both peaks were close than 1 (graphics not shown) . The slopes obtained in the last study were 0.867 in −0.4 V (first peak) and 0.987 in −1.05 V (second peak).…”

Section: Resultsmentioning

confidence: 97%

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Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

2017

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The differential pulse adsorptive cathodic stripping voltammetry (DP-AdsCSV) employing the hanging mercury drop electrode (HMDE) was used towards the determination of two psychotropic drugs in environmental samples. Voltammetric and experimental conditions to Clonazepam (CLO) and diazepam (DIAZ) were optimized and the methods were in-house validated. Accumulation potentials were À0.3 V to CLO and À0.6 V to DIAZ at 120 s of accumulation time. Pulse amplitude, pulse time and scan rate were 80 mV, 20 ms and 25 mV s À1to CLO and 100 mV, 20 ms and 40 mV s À1 to DIAZ, respectively. Recovery tests were done in three different concentrations to evaluate methods' accuracy and the results were from 88 AE 6 to 120 AE 13 %. In precision tests, standard deviations were lower than 15 % for both methods. Goods limits of quantification 0.65 and 0.27 mg L À1 to CLO and DIAZ respectively were achieved without pre-concentration steps such as SPE, etc. Voltammetry employing HMDE was first used for the determination of CLO and DIAZ in natural water. Natural samples were spiked and recovery tests confirmed the applicability of the methods developed. Nine samples from Parana state, Brazil, were analyzed and CLO and DIAZ values were below the limits of detection in all samples.

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Section: Resultsmentioning

confidence: 97%

“…The I p augments proportionally with the increase of υ (Y=2.174+0.377×X, r=0.999). Graphics of I p versus υ 1/2 (nonlinear) and log I p versus log υ (slope, 0921) confirmed an adsorption‐controlled process to DIAZ . The same adsorption‐controlled process was previously reported for ALP .…”

Section: Resultsmentioning

confidence: 99%

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

2017

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“…[20][21][22][23][24] The fabrication of the working electrode with nanoparticles enhances peak current, sensitivity, reproducibility. 25,26 In current science and technology, one of the crucial uniqueness is to survey and to discover the new efficient materials as electrode surface modifiers.In general, new types of sensor devices are the outcome of the synthesis and preparation of innovative modifiers. In this regard, as electrode surface modifiers, TiO 2 nanoparticles captured the copious interest of researchers and a considerable amount of research was executed in the previous decades, due to its photocatalytic effect, porosity, steadiness, crystallinity, widespread bandgap, high surface area and low toxicity.…”

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confidence: 99%

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Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Shetti

Nayak

Malode

et al. 2016

J. Electrochem. Soc.

104

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In the current research, ruthenium stood a conspicuous dopant for TiO 2 nanoparticles, to enhance its catalytic activity. The characterization of synthesized nanoparticles was accomplished by utilizing XRD, SEM, EDX and TEM analysis. The sensing surface morphology was studied by AFM analysis. Further, we established the electrochemical behavior and detection of flufenamic acid (FFA) by utilizing ruthenium doped TiO 2 nanoparticles modified carbon paste electrode (Ru-TiO 2 /CPE) at pH 6.0 by employing different voltammetric techniques. Modification enhances the electro-oxidation of flufenamic acid with increased current intensity. The influence of parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the peak current of the drug were studied. The effect of FFA concentration variation was studied using square wave voltammetric (SWV) technique and got lowest detection limit compared to reported techniques. The fabricated sensor was employed for the determination of flufenamic acid in biological samples. Flufenamic acid (FFA), N-(α,α,α-trifluoro-m-tolyl) an anthranilic acid derivative (Scheme 1), is an effective analgesic, an antiinflammatory and antipyretic agent used for the relief of pain and inflammation associated with musculoskeletal and joint disorders, peri-articular and soft tissue disorders, antirheumatic therapy.1,2 Monitoring of therapeutic drug habitually necessitates its detection in biological fluids.Many analytical methods based on different principles, such as spectrophotometry, 3-6 spectrofluorimetry, 5,11 fluorescence spectrometry, 7-10 flow injection analysis, 11,12 chromatography [13][14][15] have been developed for the analysis of flufenamic acid along with its derivatives. Capillary electrophoresis [16][17][18] is an alternative methodology for the separation and detection of FFA. However, these methods are well-demonstrated and broadly accepted, but they require moderately costly equipment, laborious sample pretreatment, specialized expertise, high cost and are time-consuming which make them unsuitable for routine analysis. Few voltammetric studies 5,19 were also carried out by utilizing cyclic voltammetry and adsorptive voltammetry. Though, these sensors suffer from the less sensitive, poor long-term stability, lack of surface renewability, etc.As of late, research developed, aiming at the construction and the characterization of the electrodes composed of carbonaceous materials because of their rich surface chemistry, lower background current, wider potential window, uncomplicated surface renewal and low detection limit properties. [20][21][22][23][24] The fabrication of the working electrode with nanoparticles enhances peak current, sensitivity, reproducibility. 25,26 In current science and technology, one of the crucial uniqueness is to survey and to discover the new efficient materials as electrode surface modifiers.In general, new types of sensor devices are the outcome of the synthesis and preparation of innovative modifiers. In this regard, as e...

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“…For DPV studies, the following parameters were maintained: Sweep rate-20 mV/s, pulse amplitude-50 mV, pulse width-60 ms, pulse period-500 ms for analytical applications. All experiments were carried out at 25±1°C [32][33][34][35].…”

Section: Analytical Proceduresmentioning

confidence: 99%

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

Shetti

2017

Asian J Pharm Clin Res

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Objective: This study was undertaken to propose electro-oxidation mechanism and to develop a selective and sensitive method for the determination of an anti-cancer drug, pemetrexed disodium (PTD). Methods:The electrochemical oxidation of anti-cancer drug PTD has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentration, scan rate, and excipients were investigated to optimize the experimental conditions.Results: According to the liner relation between peak potential, peak current, scan rate and PTD concentration, differential pulse voltammetric method for the quantitative determination in phosphate buffer solution was developed. The linear response was obtained in the range of 10 μM to 0.75 μM with a detection limit of 0.19 μM. The electrochemical oxidation of mechanism of anti-cancer drug PTD was proposed. Conclusion:The proposed method is rapid and does not include any time-consuming steps. The simplicity, sensitivity, and low cost of analysis are the main features of the proposed method for the determination of PTD.

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Electro-sensing base for mefenamic acid on a 5% barium-doped zinc oxide nanoparticle modified electrode and its analytical application

Abstract: In the present work, surface enhanced electro-oxidation of mefenamic acid (MFA) at a glassy carbon electrode modified with 5% barium doped ZnO nanoparticles was studied.

Cited by 79 publications

References 64 publications

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

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Electro-sensing base for mefenamic acid on a 5% barium-doped zinc oxide nanoparticle modified electrode and its analytical application

Abstract: In the present work, surface enhanced electro-oxidation of mefenamic acid (MFA) at a glassy carbon electrode modified with 5% barium doped ZnO nanoparticles was studied.

Cited by 79 publications

References 64 publications

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

Determination of Diazepam and Clonazepam in Natural Water – a Voltammetric Study

Electrochemical Sensor Based upon Ruthenium Doped TiO2Nanoparticles for the Determination of Flufenamic Acid

Electrochemical Oxidation and Determination of an Anti-Cancer Drug Pemetrexed Disodium

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Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid