Electroacupuncture Ameliorates Cognitive Deficit and Improves Hippocampal Synaptic Plasticity in Adult Rat with Neonatal Maternal Separation

Guo, Liheng; Liang, Ximin; Liang, Zhanmou; Li, Xilin; Jiang, He; Zheng, Yao; Yao, Lin; Chen, Yongjun

doi:10.1155/2018/2468105

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…MS induces both functional and structural changes in several brain regions including the PFC, hippocampus, amygdala and nucleus accumbens (150,158–163) . More specifically, impaired synaptic long-term potentiation, dendritic atrophy as well as reduced dendritic spine density have been reported in the medial PFC and hippocampus of adolescent and adult MS rats (63,68,97,104,116,140,153,158,164–171) . By contrast, MS induces dendritic hypertrophy in the amygdala (57) .…”

Section: The Maternal Separation Modelmentioning

confidence: 95%

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives

Rincel

Darnaudéry

2019

Proc. Nutr. Soc.

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The developmental period constitutes a critical window of sensitivity to stress. Indeed, early-life adversity increases the risk to develop psychiatric diseases, but also gastrointestinal disorders such as the irritable bowel syndrome at adulthood. In the past decade, there has been huge interest in the gut–brain axis, especially as regards stress-related emotional behaviours. Animal models of early-life adversity, in particular, maternal separation (MS) in rodents, demonstrate lasting deleterious effects on both the gut and the brain. Here, we review the effects of MS on both systems with a focus on stress-related behaviours. In addition, we discuss more recent findings showing the impact of gut-directed interventions, including nutrition with pre- and probiotics, illustrating the role played by gut microbiota in mediating the long-term effects of MS. Overall, preclinical studies suggest that nutritional approaches with pro- and prebiotics may constitute safe and efficient strategies to attenuate the effects of early-life stress on the gut–brain axis. Further research is required to understand the complex mechanisms underlying gut–brain interaction dysfunctions after early-life stress as well as to determine the beneficial impact of gut-directed strategies in a context of early-life adversity in human subjects.

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Section: The Maternal Separation Modelmentioning

confidence: 95%

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives

Rincel

Darnaudéry

2019

Proc. Nutr. Soc.

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“…In line with the notion that DH is involved in spatial memory, rats that went through MS show a deficit in spatial memory in the Morris Water Maze (MWM) task [100]. Another study using a longer MS protocol (PND 1-20) demonstrated a similar reduction in the dorsal SC-CA1 LTP in vivo and a spatial deficit in the MWM task in adulthood [101]. Accordingly, the LBN model of early life stress also leads to an LTP impairment at the dorsal SC-CA1 synapse during adulthood [102,103].…”

Section: Plasticity In Early Life Stress Models: Diversity Across Thementioning

confidence: 67%

Long-Term Impact of Early-Life Stress on Hippocampal Plasticity: Spotlight on Astrocytes

Çalışkan

Müller

Albrecht

2020

IJMS

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Adverse experiences during childhood are among the most prominent risk factors for developing mood and anxiety disorders later in life. Early-life stress interventions have been established as suitable models to study the neurobiological basis of childhood adversity in rodents. Different models such as maternal separation, impaired maternal care and juvenile stress during the postweaning/prepubertal life phase are utilized. Especially within the limbic system, they induce lasting alterations in neuronal circuits, neurotransmitter systems, neuronal architecture and plasticity that are further associated with emotional and cognitive information processing. Recent studies found that astrocytes, a special group of glial cells, have altered functions following early-life stress as well. As part of the tripartite synapse, astrocytes interact with neurons in multiple ways by affecting neurotransmitter uptake and metabolism, by providing gliotransmitters and by providing energy to neurons within local circuits. Thus, astrocytes comprise powerful modulators of neuronal plasticity and are well suited to mediate the long-term effects of early-life stress on neuronal circuits. In this review, we will summarize current findings on altered astrocyte function and hippocampal plasticity following early-life stress. Highlighting studies for astrocyte-related plasticity modulation as well as open questions, we will elucidate the potential of astrocytes as new targets for interventions against stress-induced neuropsychiatric disorders.

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“…Using isoflurane (RWD, Shenzhen, China), the EA rats were positioned in the induction case with an anesthetized concentration of 5% for the initial 5 min for deep anesthetized condition, and then they were moved to the EA operating platform with a 2% concentration for the middle 10 min, decreasing to 1.5% for the last 5 min. Disposable acupuncture needles as previous reported (Guo et al, 2018) were inserted to the acupoints of GV20 and GV29. The Master-8 Stimulator (Master-8, AMPI, Israel) was connected to deliver electrical current to the needles.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, as acupuncture or EA can ameliorate depressive-like behaviors, a rat model of depression is a tool that has been widely used to investigate the antidepressant effects of acupuncture (Lu et al, 2016, 2017; Jiang et al, 2017). “Baihui” (GV 20) – “Yintang” (GV 29) are considered to be the optimized acupoint modules for mental illness (Duan et al, 2009a, 2014; Jiang et al, 2017), and our previous study indicates that EA at GV 20–GV 29 acupoints ameliorates cognitive deficits and improves hippocampal synaptic plasticity in adult rats with neonatal MS (Guo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

et al. 2019

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Maternal separation (MS), a stressful event in early life, has been linked to neuropsychiatric disorders later in life, especially depression. In this study we investigated whether treatment with electroacupuncture (EA) could ameliorate depression-related manifestations in adult animals that had adverse early life experiences. We demonstrated depression-like behavior deficiencies in a sucrose preference test and a forced swimming test in a rat model with neonatal MS. Repeated EA treatment at the acupoints Baihui (GV20) and Yintang (GV29) during adulthood was shown to be remarkably attenuated above behavioral deficits. Using unbiased genome-wide RNA sequencing to investigate alterations in the transcriptome of the prefrontal cortex (PFC), we explored the altered gene sets involved in circadian rhythm and neurotransmitter transporter activity in MS rats, and their expression tended to be reversed after EA treatment. In addition, we analyzed the interaction network of differentiated lncRNA– or circRNA–miRNA–mRNA by using the principle of competitive endogenous RNA (ceRNA). These results suggest that EA at GV20 and GV29 ameliorates depression-related manifestations by regulating the expression of multiple genes.

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Electroacupuncture Ameliorates Cognitive Deficit and Improves Hippocampal Synaptic Plasticity in Adult Rat with Neonatal Maternal Separation

Cited by 9 publications

References 54 publications

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives

Maternal separation in rodents: a journey from gut to brain and nutritional perspectives

Long-Term Impact of Early-Life Stress on Hippocampal Plasticity: Spotlight on Astrocytes

Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture

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