Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats

Zhang, Can; Chen, Tan; Fan, Mingwei; Tian, Jinlan; Zhang, Shuhui; Zhao, Zijian; Liu, Xinru; Ma, Huaiyuan; Yang, Lijuan; Chen, Yan

doi:10.1016/j.neurot.2024.e00369

Neurotherapeutics

2024

DOI: 10.1016/j.neurot.2024.e00369

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Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats

Can Zhang,

Tan Chen,

Mingwei Fan

et al.

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2024

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Cited by 2 publications

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The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

Liang,

Wei,

et al. 2024

Neuroscience & Biobehavioral Reviews

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The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

Liang,

Wei,

et al. 2024

Neuroscience & Biobehavioral Reviews

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Electroacupuncture versus 5-HT4 receptor agonist for functional constipation: A systematic review and meta-analysis of randomized controlled trials

Xu,

Li,

Wang

2024

Medicine

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Background: Functional constipation (FC) has been found as a chronic gastrointestinal disease that is commonly diagnosed in patients. However, patients have a low satisfaction level with the treatment of constipation drugs (e.g., 5-HT4 agonists). A meta-analysis was performed to compare the efficacy and safety between electroacupuncture and 5-HT4 agonists. Methods: The included study were randomized controlled trials (RCTs), in which EA was used in the experimental group and 5-HT4 receptor agonist was used in the control group. Four English databases (PubMed, Cochrane Library, Web of Science, Embase) and 4 Chinese databases (China National Knowledge Infrastructure, CBM, WanFang, VIP) were searched. Relevant studies retrieved were published before September 30, 2024. The risk of bias was assessed by tool of Cochrane and GRADEpro. The Review Manager 5.4 was used for analyzing Data analysis, and Endnote X9 for screening studies. Results: In this paper, we included 12 studies, involving 1473 participants. We found that EA significantly improved patient assessment of cab quality of life questionnaire (PAC-QOL) (MD = −0.52, P = .03), self-rating anxiety scale (SAS) (MD = −3.00, P < .00001) and self-rating depression scale (SDS) (MD = −4.13, P < .00001) compared with 5-HT4 receptor agonists. In addition, we failed to identify any significant difference in Stool consistency, the number of weekly complete spontaneous bowel movements and weekly spontaneous bowel movements (SBMs) between the 2 groups. Conclusion: EA has been indicated to be better than 5-HT4 receptor agonists since it can more effectively improve FC patients’ life quality and mental state without an increased risk of adverse even. However, the previous evidence is characterized by low quality and small sample size, which should be further confirmed by high-quality and large-sample multicenter RCTs.

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Electroacupuncture improves gastrointestinal motility through a central-cholinergic pathway-mediated GDNF releasing from intestinal glial cells to protect intestinal neurons in Parkinson's disease rats

Cited by 2 publications

References 54 publications

The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

The role of enteric nervous system and GDNF in depression: Conversation between the brain and the gut

Electroacupuncture versus 5-HT4 receptor agonist for functional constipation: A systematic review and meta-analysis of randomized controlled trials

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