Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats

Cheng, Jie; Liu, Weimin; Wang, Ying; Cao, Qing; Ni, Ying; Zhang, Wenyi; Guo, Jiamei; Chen, Binglin; Zang, Yaning; Zhu, Yichao

doi:10.1111/1751-7915.13968

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…In particular, we identified a significant and region-specific decrease in the mucosal concentration of ACh in the right colon and lower 5-HT concentration in the left colon as compared to that of CTs. A similar reduction of 5-HT was reported in a model of rat SCI 38 . In addition, we also observed an increased SERT mRNA expression, which could reduce the bioavailability of 5-HT and further contribute to constipation in SCI patients.…”

Section: Discussionsupporting

confidence: 86%

“…However, the ability of IL-1β to regulate TPH1 mRNA expression remains unknown. The importance of this altered 5-HT in gastrointestinal motility disturbances is also further highlighted by the fact that therapeutic approaches for improving motility in preclinical models of SCI, such as electroacupuncture 38 or microbiota transfer 39 , are associated with the restoration of 5-HT levels. Moreover, 5-HT4R agonists such as prucalopride 40 demonstrably improve colonic transit time in SCI patients.…”

Section: Discussionmentioning

confidence: 99%

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Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Lefèvre,

Le Roy,

Bessard

et al. 2023

Sci Rep

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Patients with spinal cord injury (SCI) suffer from major bowel dysfunction, whose exact pathophysiology, particularly the involvement of the enteric nervous system or epithelial dysfunction is poorly understood. Herein, we aimed to characterize the mucosal biopsies of the right and left colon in SCI patients vs controls (CT): (1) remodeling of key enteric neurotransmitters, (2) remodeling of enteroendocrine cells, and (3) mucosal inflammation compared to those in controls. In SCI, mucosal ACh concentration was lower in the right colon as compared to CT, but no change was observed in the left colon, and AChE expression was lower in both the right and left colons than in CT. While the VIP concentration was similar in the right and left colons, VIP mRNA expression was increased in the right colon and decreased in the left colon, in SCI patients as compared to CT. Interestingly, 5-HT concentration was reduced in the left colon but not in the right colon in SCI patients. Moreover, in SCI patients, as compared to CT, SERT mRNA expression was selectively increased in the left colon while TPH1 mRNA expression was increased in the right and left colons. Although mucosal TNFα and IL-1β mRNA expression did not significantly differ between SCI and CT groups, we identified a significant positive correlation between TNFα and IL-1β mRNA expression and left colon transit time in the SCI group. In conclusion, region-specific changes occur in the enteric neurotransmitter, serotonergic, and inflammatory pathways in the colon of SCI patients. The significant correlations between these pathways and clinical parameters in the left colon further set a scientific basis for designing therapeutic targets to improve colonic motor dysfunction in patients.Biobank information: Spinal cord injury patients: PHRC ConstiCAPE—clinical trial NCT02566746. Controls: Anosain—clinical trial NCT03054415 and biobank of the “Institut des Maladies de l’Appareil Digestif (IMAD)” registered under number DC-2008-402.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Lefèvre,

Le Roy,

Bessard

et al. 2023

Sci Rep

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“…When treating SCI, it was discovered in a therapeutic study that some therapeutic techniques, including melatonin, electroacupuncture, and minocycline, also regulate the microbiota (120,121). This might offer a fresh concept and treatment objective for SCI.…”

Section: Microbiomicsmentioning

confidence: 99%

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Xu¹,

Zhao²,

Zhou³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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“…Spinal cord injuryinduced gut dysbiosis could be alleviated also due to melatonin treatment [76] and by treatment with a fecal transplant as well [77]. Furthermore, electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats [78]. Moreover, Schmidt et al [79] have showed that that minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota.…”

Section: Promising Modulation Strategies Of Sci-induced Microglial Pl...mentioning

confidence: 99%

Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury

Lukáčová¹,

Kisucká²,

Bimbová³

et al. 2021

IJMS

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Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises numerous cell populations. It is driven by the immediate response of macrophages and microglia, which triggers activation of genes responsible for the dysregulated microenvironment within the lesion site and in the spinal cord parenchyma immediately adjacent to the lesion. Recently published data indicate that microglia induces astrocyte activation and determines the fate of astrocytes. Conversely, astrocytes have the potency to trigger microglial activation and control their cellular functions. Here we review current information about the release of diverse signaling molecules (pro-inflammatory vs. anti-inflammatory) in individual cell phenotypes (microglia, astrocytes, blood inflammatory cells) in acute and subacute SCI stages, and how they contribute to delayed neuronal death in the surrounding spinal cord tissue which is spared and functional but reactive. In addition, temporal correlation in progressive degeneration of neurons and astrocytes and their functional interactions after SCI are discussed. Finally, the review highlights the time-dependent transformation of reactive microglia and astrocytes into their neuroprotective phenotypes (M2a, M2c and A2) which are crucial for spontaneous post-SCI locomotor recovery. We also provide suggestions on how to modulate the inflammation and discuss key therapeutic approaches leading to better functional outcome after SCI.

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Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats

Cited by 17 publications

References 45 publications

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Region-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients

Multi-omics in Spinal Cord Injury: Diagnosis, Prognosis, and Treatment

Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury

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