Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s Disease: Using Morris Water Maze and Micro-PET

Jiang, Jing; Gao, Kai; Zhou, Yuan; Xu, Anping; Shi, Suhua; Liu, Gang; Li, Zhigang

doi:10.1155/2015/142129

Cited by 38 publications

(38 citation statements)

References 37 publications

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“…It was shown that senescence-accelerated mouse (SAMP8), as a model of aging, displays many features known to occur in the early stage of AD such as increased oxidative stress, amyloid-beta level alteration, and tau phosphorylation [12]. What is more, published data [13] and our previous research [5] demonstrated that SAMP8 could undergo acupuncture therapy to improve learning and memory ability. In this study, therefore, SAMP8 mice were selected as an ideal animal model for Alzheimer's disease.…”

Section: Discussionmentioning

confidence: 99%

“…This therapy has been applied for AD treatment and could improve the cognitive function [26] and brain energy metabolism [5, 27]. Therefore, EA is considered an effective therapeutic intervention for AD [28].…”

Section: Discussionmentioning

confidence: 99%

“…We previously demonstrated that treatment with electroacupuncture could effectively improve the spatial learning and memory ability as well as glucose metabolism in the hippocampus of animals with AD [5]. Other studies suggested that music therapy could contribute to a supplementary treatment of AD [6].…”

Section: Introductionmentioning

confidence: 99%

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Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

Jiang

Liu²,

Shi

et al. 2016

Neural Plasticity

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Objectives. To compare musical electroacupuncture and electroacupuncture in a mouse model of Alzheimer's disease. Methods. In this study, 7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an Alzheimer's disease animal model. In the normal control paradigm, 7.5-month-old male SAMR1 mice were used as the blank control group (N group). After 15 days of treatment, using Morris water maze test, micro-PET, and immunohistochemistry, the differences among the musical electroacupuncture (MEA), electroacupuncture (EA), Alzheimer's disease (AD), and normal (N) groups were assessed. Results. The Morris water maze test, micro-PET, and immunohistochemistry revealed that MEA and EA therapies could improve spatial learning and memory ability, glucose metabolism level in the brain, and Aβ amyloid content in the frontal lobe, compared with the AD group (P < 0.05). Moreover, MEA therapy performed better than EA treatment in decreasing amyloid-beta levels in the frontal lobe of mice with AD. Conclusion. MEA therapy may be superior to EA in treating Alzheimer's disease as demonstrated in SAMP8 mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

Jiang

Liu²,

Shi

et al. 2016

Neural Plasticity

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“…There exists some indivisible relations between Governor Vessel (GV) and brain, both in distribution and in function. Clinical and experimental studies have shown that acupuncture at GV possessed therapeutic effects in AD treatment (Yang et al, 2013; Jiang et al, 2015; Wang et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Behavioral Changes and Hippocampus Glucose Metabolism in APP/PS1 Transgenic Mice via Electro-acupuncture at Governor Vessel Acupoints

Cao

Tang

et al. 2017

Front. Aging Neurosci.

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Objective: Investigating the effects of electro-acupuncture (EA) treatment on mice with Alzheimer’s disease (AD), using Morris water maze (MWM) for spatial learning and memory behavior tests combined with micro-positron emission tomography (micro-PET) imaging for glucose metabolism in hippocampus.Methods: Thirty seven-month-old APP/PS1 mice were randomly divided into AD Model group (AD group), medicine group (M group) and EA group, C57BL/6 mice were used for Normal control group (N group), n = 10 in each group. Mice in M group received donepezil intervention by gavage with dose at 0.92 mg/kg. EA was applied at Baihui (GV20) and Yintang (GV29) acupoints for 20 min then pricked at Shuigou (GV26) acupoint, while mice in N, M and AD groups were received restriction for 20 min, with all treatment administrated once a day for 15 consecutive days. After the treatment, MWM was performed to observe behavioral changes in mice, then hippocampus glucose metabolism level was tested by micro-PET imaging.Results: Compared with that of AD group, the escape latency of M and EA groups declined significantly (P < 0.01), while the proportion of the platform quadrant swimming distance in total swimming distance showed an obvious increase (P < 0.01), and EA group occupied a higher percentage than that in M group. The micro-PET imaging showed that mice in AD group performed a lower glucose metabolic rate in hippocampus compared with N group (P < 0.01). Both M and EA groups presented a significant higher injected dose compared with AD group (P < 0.01), and the uptake rate of EA group was higher than M group.Conclusion: Both donepezil and EA have therapeutic effects on AD mice. To a certain extent, EA shows a better efficacy in treatment of AD by improving the spatial learning and memory ability, while also enhancing glucose metabolism in hippocampus.

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“…2a). The shortest possible time to find the platform is interpreted as a better learning and memory21. We found no difference of spatial learning and memory between WT mice and PAFR −/− mice in MWM task (Fig.…”

Section: Resultsmentioning

confidence: 68%

Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury

Yin

Chen

Zhu

et al. 2017

Sci Rep

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Traumatic brain injury (TBI) is a principal cause of death and disability worldwide, which is a major public health problem. Death caused by TBI accounts for a third of all damage related illnesses, which 75% TBI occurred in low and middle income countries. With the increasing use of motor vehicles, the incidence of TBI has been at a high level. The abnormal brain functions of TBI patients often show the acute and long-term neurological dysfunction, which mainly associated with the pathological process of malignant brain edema and neuroinflammation in the brain. Owing to the neuroinflammation lasts for months or even years after TBI, which is a pivotal causative factor that give rise to neurodegenerative disease at late stage of TBI. Studies have shown that platelet activating factor (PAF) inducing inflammatory reaction after TBI could not be ignored. The morphological and behavioral abnormalities after TBI in wild type mice are rescued by general knockout of PAFR gene that neuroinflammation responses and cognitive ability are improved. Our results thus define a key inflammatory molecule PAF that participates in the neuroinflammation and helps bring about cerebral dysfunction during the TBI acute phase.

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Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer’s Disease: Using Morris Water Maze and Micro-PET

Cited by 38 publications

References 37 publications

Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

Musical Electroacupuncture May Be a Better Choice than Electroacupuncture in a Mouse Model of Alzheimer’s Disease

Behavioral Changes and Hippocampus Glucose Metabolism in APP/PS1 Transgenic Mice via Electro-acupuncture at Governor Vessel Acupoints

Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury

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