2024
DOI: 10.1073/pnas.2415047121
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Electrocalcium coupling in brain capillaries: Rapidly traveling electrical signals ignite local calcium signals

Amreen Mughal,
Grant W. Hennig,
Thomas Heppner
et al.

Abstract: The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients. We recently identified two capillary endothelial cell (cEC)-based mechanisms that control cerebral blood flow in vivo: 1) electrical signaling, mediated by extracellular K + -dependent activation of strong inward rectifying K + (Kir2.1) channels, which are steeply ac… Show more

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