Electrocatalysis as a key strategy for the total synthesis of natural products

Abstract

Electrochemical strategy has been the powerful approach for the synthesis of valuable intermediates, in particular heterocyclic motifs. It has proven to be an environmentally benign, highly effective and versatile platform...

The Application of Sulfonyl Hydrazides in Electrosynthesis: A Review of Recent Studies

“…Among sulfone-type compounds, β-keto-sulfones are a class of valuable chemical intermediates. 60 In 2020, the Xu group reported the oxysulfonylation of alkenes toward β-ketosulfones (35) using sulfonyl hydrazides (33) and styrenes (34) with an electrochemical method (Scheme 6). 61 To obtain the desired products, an undivided cell equipped with an RVC anode and a Pt cathode was employed.…”

“…These unfavorable disadvantages have limited the further applications of these thesis. 34 As a profound synthetic tool, it is indisputable that electrosynthesis has a hopeful future. 35,36 Due its the important role, there have been several reviews about sulfonyl hydrazides focusing on different aspects.…”

“…Recently, several reports on the electrochemical application of sulfonyl hydrazides indicated that electrosynthesis could be one of the solutions to this problem. As known to all, the use of external oxidants or reductants could be limited to a certain extent in electrochemical reactions, and there are many advantages for electrosynthesis over traditional methods. − Therefore, electrosynthesis is green, efficient, and environmental-friendly, and has been widely applied in synthetic methodology development − and natural product synthesis . As a profound synthetic tool, it is indisputable that electrosynthesis has a hopeful future. , …”

“… 26 − 28 Therefore, electrosynthesis is green, efficient, and environmental-friendly, and has been widely applied in synthetic methodology development 29 − 33 and natural product synthesis. 34 As a profound synthetic tool, it is indisputable that electrosynthesis has a hopeful future. 35 , 36…”

Copper-catalyzed cascade reaction of tryptamines with diazo compounds to access hexahydropyrroloindoline derivatives

“…1 Moreover, complex indoline alkaloids with an additional tertiary stereocenter (C3′) adjacent to the C3 quaternary center, are highly appealing due to their wide presence and activity in biology. Although several attractive synthetic strategies have been developed towards the synthesis of core pyrroloindoline structures, 2 the development of efficient methods to construct three contiguous stereogenic centers in one step remains a formidable challenge in synthetic chemistry. The groups of Liu and You have developed asymmetric propargylic dearomatization of indoles to provide furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center.…”