Electrochemical Aptasensor for the Determination of Cocaine Incorporating Gold Nanoparticles Modification

Li, Xiaoxia; Qi, Honglan; Shen, Linyong; Gao, Qiang; Zhang, Chengxiao

doi:10.1002/elan.200704193

Cited by 59 publications

(22 citation statements)

References 41 publications

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“…Metal NPs such as Pt NPs [20] or Au NPs [21] have been used as catalytic labels for signal amplification in amperometric aptasensors. Their presence on the electrode surface has also been shown to produce signal enhancement, thus giving rise to a better sensitivity [29,68].…”

Section: Discussionmentioning

confidence: 99%

“…Such an aptasensor presents a simple architecture, is generalizable, selective and usable in complex real samples. Signal enhancement by self-assembling gold NPs onto a gold electrode has recently been demonstrated with a signal-on electrochemical aptasensor based on immobilization of ferrocene-labeled aptamers [29]. Thiolated redox-active aptamers were self-assembled on gold NPs.…”

Section: Other Covalently Linked Redox Speciesmentioning

confidence: 99%

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Electrochemical Aptasensors

2009

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This review presents electrochemical aptasensors reported in the literature. Their development has been growing as evidenced by the increasing number of scientific publications on this subject since 2004. Aptasensors are presented according to their transduction mode, including the most described amperometric and impedimetric devices as well as FETs and the first very recently reported potentiometric aptasensor. Signal-on (positive readout signal) and less sensitive signal-off (negative readout signal) aptasensors are reviewed based on target binding-induced conformational change of aptamers or on target binding-induced strand displacement or even on both processes. Aptamerlabeled and aptamer label-free devices are presented separately.

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Section: Discussionmentioning

confidence: 99%

Section: Other Covalently Linked Redox Speciesmentioning

confidence: 99%

Electrochemical Aptasensors

2009

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“…Another electrochemical aptasensor for the determination of cocaine based on signal enhancement was reported utilizing AuNPs self-assembled on the gold electrode [104]. As shown in Fig.…”

Section: Aunps As Substrates In Electrochemical Aptasensorsmentioning

confidence: 99%

“…10 a The electrochemical aptasensor of Fc-labeled anti-cocaine aptamer for the detection of cocaine [104]. b Schematic representation of AuNP electrochemical sensing platform for aptamer-thrombin interaction [105].…”

Section: Aunps As Substrates In Electrochemical Aptasensorsmentioning

confidence: 99%

Analytical potential of gold nanoparticles in functional aptamer-based biosensors

Wang

2010

Bioanal Rev

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Gold nanoparticles (AuNPs) exhibit many predominant capabilities such as high biocompatibility, chemical stability, strong localized surface plasmon resonance absorption, and high extinction coefficient in the visible region. These properties have enabled the extensive use of AuNPs in optical and electrochemical biosensors. As a kind of functional nucleic acids, aptamers can be considered as a valid alternative to antibodies or other bio-receptors and have been widely employed to develop novel biosensors. We are summarizing here the state of the art of AuNP-based biosensors that use functional aptamers as molecular recognition elements. In many cases, AuNPs themselves can be used as a probe for detection, such as various colorimetric aptasensors and fluorescent aptasensors. They also can be used as probe vectors to enlarge detection signals and to increase the number of conceivable substrates in electrochemical aptasensors.

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“…However, the analytical signal was significantly inhibited in these samples limiting their real applicability. The amount of labeled aptamer immobilized can be increased by assembling AuNPs to a Au electrode through a dithiol linker resulting in an improved detectability [74].…”

Section: Labeling Strategies: Self-reporting Assaysmentioning

confidence: 99%

Structured Nucleic Acid Probes for Electrochemical Devices

Miranda‐Castro¹,

de‐los‐Santos‐Álvarez²,

Lobo-Castañón³

et al. 2009

Electroanalysis

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The use of nucleic acid with a specific sequence and a highly ordered secondary structure such as hairpins, quadruplexes and pseudoknots as biological recognition elements and switches in biosensors is rapidly increasing because of their improved features (e.g. selectivity) when compared with the traditional linear probes. Owing to the novelty, a critical outlook of their characteristics and a compilation of the latest advances are lacking. This article describes the potential of those nucleic acids probes whose molecular recognition ability relies on a conformational change (e.g. folding/unfolding mechanism) in electrochemical sensing. It provides an overview of the toolbox of assays using these probes for genosensors and aptasensors, highlighting its performance characteristics and the prospects and challenges for biosensor design.

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Electrochemical Aptasensor for the Determination of Cocaine Incorporating Gold Nanoparticles Modification

Cited by 59 publications

References 41 publications

Electrochemical Aptasensors

Electrochemical Aptasensors

Analytical potential of gold nanoparticles in functional aptamer-based biosensors

Structured Nucleic Acid Probes for Electrochemical Devices

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