Electrochemical assay system with single-use electrode strip for measuring lactate in whole blood

Shimojo, Nobuo; Naka, Keiichi; Uenoyama, Harumi; Hamamoto, K; Yoshioka, Katsunobu; Okuda, Kiyoshi

doi:10.1093/clinchem/39.11.2312

Cited by 79 publications

(41 citation statements)

References 8 publications

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“…13 The test is carried out at the bedside, and the result is available after 60 seconds. [13][14][15][16] The meter measures lactate concentrations between 0.8 and 23 mmol/l and has an in between run coefficient of variation of £3%. Values less than 0.8 mmol/l are measured as 'low' and in this study, values are presented as 0.5 mmol/l.…”

Section: Methodsmentioning

confidence: 99%

Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes

Wiberg-Itzel

Pettersson

Cnattingius

et al. 2006

BJOG

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Objectives To assess whether lactate determination in vaginal fluid is associated with, and can predict, onset of labour for women with suspected prelabour rupture of the membranes (PROM).Design Prospective observational study.Setting Labour ward at Soder Hospital, Stockholm, Sweden.Population Women with suspected PROM after 34 weeks of gestation, who later had spontaneous onset of labour (n = 179).Methods All women underwent a speculum examination and a test for determining lactate concentration in vaginal fluid. We used logistic regression to estimate the association between lactate concentration in vaginal fluid and time to onset of labour.Main outcome measures Time from examination to onset of labour (cervix ‡4 cm), within 24 hours and 48 hours.Results The median time interval between examination and spontaneous onset of labour was 8.4 hours for women with 'high' lactate ( ‡4.5 mmol/l) and 54 hours for those with 'low' lactate concentrations (<4.5 mmol/l). Among 86 women with high lactate concentrations, 76 (88%) had started labour within 24 hours compared with 20 of 93 (22%) women with low lactate concentrations (OR 27.7,. After checking for the effect of visible amniotic fluid, the corresponding odds were still substantially increased (OR 13.5, 95% CI 5.3-34.3).Conclusions High lactate concentration ( ‡4.5 mmol/l) in vaginal fluid can be used to predict whether a woman with suspected PROM will commence spontaneous onset of labour within 24 or 48 hours.

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Section: Methodsmentioning

confidence: 99%

Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes

Wiberg-Itzel

Pettersson

Cnattingius

et al. 2006

BJOG

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“…After spontaneous respiration became stable and immediately before application of the thigh tourniquet, arterial blood pressure, heart rate and respiratory rate were recorded, and arterial blood was collected for blood gas analysis and measurement of blood lactate and potassium levels. The lactate levels were assayed using a portable lactate testing device (Lactate Pro LT‐1710, Kyoto Daiichi Kagaku, Kyoto, Japan), which has a sensitivity level of 0.8 mmol.l −1 [6]. The extremity was exanguinated with an Esmarch bandage, and the tourniquet was inflated to a pressure of 350 mmHg, followed by initiation of the surgery.…”

Section: Methodsmentioning

confidence: 99%

Circulatory, respiratory and metabolic changes after thigh tourniquet release in combined epidural‐propofol anaesthesia with preservation of spontaneous respiration

et al. 2002

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Twelve elderly patients undergoing total knee arthroplasty received lumbar epidural anaesthesia and propofol infusion at 5 mg.kg(-1).h(-1) following a 1.5-2.0 mg.kg(-1) bolus dose with preservation of spontaneous respiration via a laryngeal mask airway. Circulatory, respiratory and metabolic variables were measured before and 1, 3, 5, 15 and 30 min after release of a pneumatic thigh tourniquet. The blood pressure was decreased at all time-points and the respiratory rate increased at 1 min. The P(a)CO(2) was increased only at 1 min. Arterial blood pH and base excess were decreased at 1 and 3 min and 1, 3 and 5 min, respectively. Arterial blood lactate levels were increased at all times. These characteristics were considered to be identical to those under regional anaesthesia with conscious spontaneous respiration, showing that spontaneous respiration under this anaesthetic regimen has a similar respiratory capacity to that of conscious spontaneous respiration.

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“…Detailed information on principles of the POC lactate meters is described elsewhere. 11,12 Statistical Analysis Data were first subjected to the PROC MEANS and UNI-VARIATE procedures to determine descriptive statistics parameters (mean, range, standard deviation, range, median, and percentiles) as well as to assess normality. h One observation was an outlier and was deleted from the dataset.…”

Section: Blood L-lactate Measurement By the Poc Lactate Metersmentioning

confidence: 99%

Evaluation of 4 Point‐of‐Care Units for the Determination of Blood l‐Lactate Concentration in Cattle

Karapinar

Kaynar

Hayırlı

et al. 2013

Veterinary Internal Medicne

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Background: Despite being used commonly in bovine medicine, information on reliability of point-of-care (POC) lactate meters is limited.Objective: To determine the validity of 4 commercially available POC lactate meters in cattle. Animals: Cattle with various diseases (n = 120).Methods: Blood samples collected from the jugular vein were processed immediately on POC lactate meters. Plasma Llactate concentration was measured by the enzymatic-colorimetric method (ELISA). Data were subjected to Friedman's test for comparison, Passing-Bablok regression and Bland-Altman plot analyses for reliability, and receiver operating characteristics analysis for sensitivity (Se) and specificity (Sp).Results: The POC lactate meters were highly correlated with ELISA (r = 0.98-0.99) despite disagreements among units. When regressed on ELISA, blood L-lactate concentrations generated from Accutrend Plus and Lactate Pro were linear up to 16.6 and 15.7 mmol/L, respectively, whereas those generated from i-STAT and Lactate Scout were linear up to 19.5 and 19.7 mmol/L, respectively. All POC lactate meters had a Se of 100% with Sp of 95.7-98.6% at a plasma L-lactate cut-off concentration of 4 mmol/L. i-STAT had the best accuracy (99.0%) and precision (99.8%), the best linear fit (y = À0.13 + 1.04X) yielding the lowest bias (À6.6%) as well as the highest Se (100%) and Sp (98.6%).Conclusions and Clinical Importance: Despite high correlation with the reference method, dilution is needed for Accutrend Plus/Lactate Pro and i-STAT/Lactate Scout if concentrations >15 and 20 mmol/L, respectively. i-STAT provided the most accurate and precise results.

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Electrochemical assay system with single-use electrode strip for measuring lactate in whole blood

Cited by 79 publications

References 8 publications

Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes

Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes

Circulatory, respiratory and metabolic changes after thigh tourniquet release in combined epidural‐propofol anaesthesia with preservation of spontaneous respiration

Evaluation of 4 Point‐of‐Care Units for the Determination of Blood l‐Lactate Concentration in Cattle

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