Electrochemical behavior, biocompatibility and mechanical performance of biodegradable iron withPEIcoating

Abstract

Coating of the biodegradable metals represents an effective way of modification of their properties. Insufficient biological, mechanical, or degradation performance of pure metals may be enhanced when the proper type of organic polymer coating is used. In our previous work, the significant effect of the polyethyleneimine (PEI) coating not only on the rate but also on the type of corrosion was discovered. To bring a comprehensive overview of the Fe-PEI system performance, iron-based biodegradable scaffolds with polyethyleneimine coating were studied and their cytocompatibility and hemocompatibility, and mechanical properties were evaluated and discussed in this work. Electrochemical impedance spectroscopy (EIS) measurements were conducted for further study of material behavior. Biological analyses (MTS assay, fluorescent imaging, hemocompatibility tests) showed better cell proliferation on the surface of Fe-PEI samples but not sufficient overall cytocompatibility. Good anti-platelet adhesion properties but higher hemolysis when compared to the pure iron was also observed for the coated samples. Mechanical properties of the prepared Fe-PEI material were enhanced after coating. These findings suggest that the Fe-PEI may be an interesting potential biomaterial after further composition optimization resulting in lower cytotoxicity and better hemocompatibility.

Biodegradable Iron and Porous Iron: Mechanical Properties, Degradation Behaviour, Manufacturing Routes and Biomedical Applications

“…Surface treatments are used primarily to enhance the biocompatibility of iron, increase the corrosion rate, and also aimed for an uniform corrosion of iron. The surface functionalization of iron to improve its biocompatibility is reported in studies including ion implantation with tantalum, with lanthanum, formation of Fe-O film, plasma nitriding, coatings with calcium phosphates and polymeric coatings [ 1 , 48 , 71 ]. Cytocompatibility and osseointegration are bioactivities improved by coating the metallic surface [ 56 ].…”

Rapid UV Photo-Cross-Linking of α-Lactalbumin Hydrogel Biomaterial To Enable Wound Healing

“…Hemolysis testing is a useful method for assessing the hemocompatibility of biological materials. In general, materials with a hemolysis rate of less than 5% are considered to have good hemocompatibility, and lower hemolysis rates indicate better hemocompatibility . In our present study, hemolysis tests were performed using different mass concentrations of α-LAMA hydrogel saline extracts (Figure a).…”

“…In general, materials with a hemolysis rate of less than 5% are considered to have good hemocompatibility, and lower hemolysis rates indicate better hemocompatibility. 30 In our present study, hemolysis tests were performed using different mass concentrations of α-LAMA hydrogel saline extracts (Figure 5a). The hemolysis rates of the α-LAMA hydrogel samples with different mass concentrations were less than 5%, which was below the assessment standard.…”

Fucoidan- and Ciprofloxacin-Doped Plasma-Activated Polymer Coatings on Biodegradable Zinc: Hemocompatibility and Drug Release

“…Even though these cracks have disturbed the layer, several cases, including our previous work, were reported where these can play the role of a canal for better electrolyte penetration and therefore play a role in corrosion process dynamics. 46,59 Effective incorporation of dopants (FU/CPR) into both polymers was confirmed by the FT-IR method. The higher loading efficiency (almost double) was observed for the PEI owing to its conductive character and therefore more efficient bonding with dopants rich in functional groups.…”

“…Polyethylenimine (PEI) is a cationic polymer that has been shown to promote cell adhesion and proliferation and has been used in various biomedical applications − as a coating or gene carrier. PEI coatings have also been used as a surface modification for BMs in our previous work to improve their biocompatibility and mechanical properties and to influence corrosion properties . Though, cytotoxicity of PEI has been a concern recently, which highlights the importance of optimizing the properties and concentration of the coating material to ensure its biocompatibility.…”