Electrochemical biosensor based on singlet oxygen generated by molecular photosensitizers

Ling, Pinghua; Sun, Xinyu; Cheng, Shan; Gao, Xianping; Gao, Feng

doi:10.1016/j.aca.2021.338970

Cited by 2 publications

(1 citation statement)

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“…The oxidation of GSH into GSSG dimer due to production of 1 O 2 by ZnTCPP, goes along with the oxidation of HQ into a benzoquinone (BQ). The successive reduction of the BQ into HQ leads to the final amplification of the current, closing the redox cycle [ 223 ].…”

Section: 1 O 2 In Bioorganic Chemistry Ap...mentioning

confidence: 99%

A Photosensitized Singlet Oxygen (1O2) Toolbox for Bio-Organic Applications: Tailoring 1O2 Generation for DNA and Protein Labelling, Targeting and Biosensing

et al. 2022

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Singlet oxygen (1O2) is the excited state of ground, triplet state, molecular oxygen (O2). Photosensitized 1O2 has been extensively studied as one of the reactive oxygen species (ROS), responsible for damage of cellular components (protein, DNA, lipids). On the other hand, its generation has been exploited in organic synthesis, as well as in photodynamic therapy for the treatment of various forms of cancer. The aim of this review is to highlight the versatility of 1O2, discussing the main bioorganic applications reported over the past decades, which rely on its production. After a brief introduction on the photosensitized production of 1O2, we will describe the main aspects involving the biologically relevant damage that can accompany an uncontrolled, aspecific generation of this ROS. We then discuss in more detail a series of biological applications featuring 1O2 generation, including protein and DNA labelling, cross-linking and biosensing. Finally, we will highlight the methodologies available to tailor 1O2 generation, in order to accomplish the proposed bioorganic transformations while avoiding, at the same time, collateral damage related to an untamed production of this reactive species.

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Section: 1 O 2 In Bioorganic Chemistry Ap...mentioning

confidence: 99%