Electrochemical Biosensor for Glycated Hemoglobin (HbA1c)

Chen, Pu; Pritzker, Mark; Sheikholeslam, Mohammadali

doi:10.5772/18105

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Biosensor adalah perangkat penginderaan kimia yang mengubah hasil reaksi biokimia menjadi sinyal terukur. Kelebihan dari biosensor adalah instrumen yang sederhana, kecepatan pengukuran, memiliki sensitivitas, selektivitas, dan stabilitas yang baik dibandingkan metode diagnostik lainnya, dan murah (Dorledo de Faria et al, 2019;Sheikholeslam et al, 2011). Komponen utama dari biosensor adalah bioreseptor dan transduser.…”

Section: Klasifikasi Biosensorunclassified

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

2023

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Hiperglikemia merupakan ciri diabetes melitus, sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Hiperglikemia dapat menyebabkan kerusakan jangka panjang, disfungsi, dan kegagalan berbagai organ, terutama jantung, mata, saraf, pembuluh darah, dan ginjal. Oleh karena itu, diagnosis dan pemantauan rutin kadar glukosa darah sangat penting dilakukan. Hemoglobin terglikasi (HbA1c) adalah hemoglobin yang berikatan dengan glukosa dalam darah dan ditetapkan menjadi biomarker hiperglikemia yang dapat mengindikasikan diabetes atau prediabetes. Akan tetapi, pengukuran HbA1c di laboratorium klinis membutuhkan instrumen yang canggih dan mahal, tenaga ahli khusus dan waktu lama. Oleh karena itu, biosensor elektrokimia kemudian mulai dikembangkan untuk mendeteksi kadar HbA1c karena mudah digunakan, hasil cepat, dan harga yang murah. Ulasan ini membahas biosensor elektrokimia untuk mendeteksi HbA1c dan metode imobilisasi bioreseptor.Electrochemical Biosensor for Monitoring Glycated Hemoglobin (HbA1c) Levels in Diabetes Mellitus. Hyperglycemia is a hallmark of diabetes mellitus, a group of metabolic diseases caused by defects in insulin action, insulin secretion, or both. Hyperglycemia can cause long-term damage, dysfunction, and failure of various organs, especially the heart, blood vessels, eyes, nerves, and kidneys.. Therefore, routine diagnosis and monitoring of blood glucose levels are very important. Glycated hemoglobin (HbA1c) is hemoglobin that binds to glucose in the blood and is established as a biomarker of hyperglycemia that may indicate diabetes or prediabetes. However, measurement of HbA1c in the clinical laboratory requires large and expensive instruments, specialized experts, and takes a long time. Therefore, an electrochemical biosensor began to be developed to detect HbA1c levels because it is easy to use and has fast results at lower prices. This review discusses electrochemical biosensors for detecting HbA1c and the immobilization of bioreceptors.

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Section: Klasifikasi Biosensorunclassified

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

2023

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Individual Glycation Sites as Biomarkers of Type 2 Diabetes Mellitus

Soboleva¹,

Vashurina²,

Frolov³

2021

Type 2 Diabetes - From Pathophysiology to Cyber Systems

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Type 2 diabetes mellitus (T2DM) is a widely spread metabolic disease, the initial stages of which are asymptomatic and have no clinically recognizable manifestation. At the molecular level, T2DM is manifested with essential non-enzymatic structural changes of intra- and extracellular proteins, mostly represented with oxidation and glycation of multiple residues. Protein glycation is one of the most universal markers of T2DM, and is recognized as an indirect, but adequate indicator of plasma glucose levels over prolonged periods of time. Unfortunately, glycated hemoglobin (HbA1c) – the universally accepted T2DM marker, is insensitive for short-term excursions of blood glucose, which are known to precede the onset of disease. Therefore, new generation biomarkers, giving access to the time dimension of Maillard reaction in blood, are desired. In this context, establishment of individual glycation sites of plasma proteins as new T2DM biomarkers might be a promising approach. Indeed, involvement of proteins with different half-life times in such analysis will make the time dimension of protein glycation in blood available and will allow early recognition of blood sugar fluctuations, occurring within few weeks or even days.

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Electrochemical Biosensor for Glycated Hemoglobin (HbA1c)

Cited by 2 publications

References 22 publications

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

Biosensor Elektrokimia untuk Memonitor Level Hemoglobin Terglikasi (HbA1c) pada Penyakit Diabetes Melitus

Individual Glycation Sites as Biomarkers of Type 2 Diabetes Mellitus

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