Electrochemical cascade migratory versus ortho-cyclization of 2-alkynylbenzenesulfonamides

Abstract

Efficient control over several possible reaction pathways of free radicals is the chemical basis of their highly selective transformations. Among various competing reaction pathways, sulfonimidyl radicals generated from the electrolysis...

Electrochemical Continuous-Flow Scholl Reaction toward Polycyclic Aromatic Hydrocarbons

“…In continuance with our research interests in synthetic electrochemistry, − we notice that the continuous-flow electrosynthesis offers an easy scale-up preparation process and can operate with electrolyte-free or minimum amount of electrolyte due to the very close distance between two electrodes. − To address the shortcomings in the electrochemical Scholl reaction in batch as described above, we herein develop an electrochemical continuous-flow (e-flow) Scholl reaction for the facile preparation of diverse PAHs (Scheme C). Further investigations reveal that this approach can be applied to the preparation of structurally complicated distorted PAHs that have been shown to possess interesting electronic and optical properties.…”