Electrochemical Detection for Capillary Electrophoresis Microchips: A Review

Abstract

Electrochemistry detection offers considerable promise for capillary-electrophoresis (CE) microchips, with features that include remarkable sensitivity, portability, independence of optical path length or sample turbidity, low cost and power requirements, and high compatibility with modern micromachining technologies. This article highlights key strategies in controlled-potential electrochemical detectors for CE microchip systems, along with recent advances and directions. Subjects covered include the design of the electrochemical detection system, its requirements and operational principles, common electrode materials, isolation from the separation voltage, derivatization reactions, typical applications, and future prospects. It is expected that electrochemical detection will become a powerful tool for CE microchip systems and will lead to the creation of truly portable (and possibly disposable) devices.

Investigating the Kinetics of Antibody Adsorption onto Polyethylene Terephthalat (PET) Modified with Gold Nanoparticles in Flow Microchannel

“…The device is designed to measure interfacial admittance on dielectric layer that is different to previously reported work on non-contact conductivity detection in capillary for electrophoresis [25][26][27][28][29][30]. A microscale device with two planar microelectrodes in non-contact mode has been used to detect adsorption of biomolecules with a good reproducibility.…”

Nanomaterials as electrochemical detectors in microfluidics and CE: Fundamentals, designs, and applications

“…(b) In some cases, the electrocatalytic effect of residual metallic nanoparticles within CNT materials [17,18] might have a strong effect on the electrocatalysis of analytes Martin Pumera 1 Alberto Escarpa and therefore on lowering the detection potentials [19][20][21][22][23]. It is clear that CNT must be properly characterized as to the amount and type of residual metallic impurities before their use [18].…”

“…Electrochemical detection offers inherent miniaturization capabilities, potential for complete integration of electrochemical detectors and control instrumentation, extremely low cost, low-power requirements, and high compatibility with advanced micromachining and microfabrication technologies. All of these are well suited to the microfluidics/microsystems concept [1][2][3][4][5][6][7][8][9][10][11].…”

Bioanalytical profile of the l-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis

“…CEECD has rapidly expanded to an attractive alternative of technologically more changing UV/LIF and CD/CCD-based technique in both conventional fused silica capillary assay and microchip-based frameworks; see for example refs. [330] and [331][332][333], respectively.…”