Electrochemical Determination of Glutathione

Будников, Г. К.; Ziyatdinova, Guzel; Valitova, Ya. R.

doi:10.1023/b:janc.0000030882.74488.44

Cited by 12 publications

(6 citation statements)

References 4 publications

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“…Taking into account the different strengths of the titrants-oxidants, there is the possibility of controlling the selectivity of the target analyte response. Thus, electrogenerated iodine does not oxidize phenolic AOs [55] and retinol [63], while it reacts with thiol-containing AOs [47][48][49][50][51] and ascorbic acid [55,59,60]. On the contrary, hexacyanoferrate(III) ions easily interact with phenolic AOs and ascorbic acid [55] but do not react with S-containing AOs.…”

Section: Quantification Of Individual Antioxidantsmentioning

confidence: 99%

“…The reaction products depend on the titrant used. For instance, thiol-containing compounds can be oxidized to disulfide, sulfoxide or sulfonic acid with the participation of two, four and six electrons, respectively [47][48][49][50][51]. Phenolic compounds are usually oxidized with the formation of o-quinone fragments [53,54,[56][57][58].…”

Section: Quantification Of Individual Antioxidantsmentioning

confidence: 99%

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Analytical Capabilities of Coulometric Sensor Systems in the Antioxidants Analysis

Ziyatdinova

Budnikov

2021

Chemosensors

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The definition of antioxidants (AOs), their classification and properties as well as electrochemical sensor systems for AOs analysis are briefly discussed. The analytical capabilities of coulometric titration with electrogenerated titrants as sensor systems for AOs determination have been considered in detail. The attention focused on the individual AO quantification that was mainly used in the pharmaceutical analysis and estimation of total antioxidant parameters (total antioxidant capacity (TAC), ferric reducing power (FRP) and ceric reducing/antioxidant capacity (CRAC)) allowing the fast screening of the target samples including their quality control. The main advantages of coulometric sensor systems are pointed out. The selective quantification of individual AO in a complex matrix using a combination of chromatography with coulometric or coulometric array detection under potentiostatic mode is discussed. The future development of coulometric sensor systems for AOs analysis is focused on the application of novel coulometric titrants and the application of coulometric detection in flow injection analysis.

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Section: Quantification Of Individual Antioxidantsmentioning

confidence: 99%

Section: Quantification Of Individual Antioxidantsmentioning

confidence: 99%

Analytical Capabilities of Coulometric Sensor Systems in the Antioxidants Analysis

Ziyatdinova

Budnikov

2021

Chemosensors

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“…Halogens are mainly used as model oxidizing agents [ 69 , 70 , 71 , 72 , 73 , 74 , 75 ], but in recent years there have been published articles concerning electric generation of other model oxidizing agents, in particular iron hexacyanoferrate [ 76 ]. The coulometry method with electro-generated titrants has a great advantage over other methods because it is standardless, does not require the preparation of standard solutions, and therefore does not require storage.…”

Section: Methods To Evaluate Integrated Antioxidant Propertiesmentioning

confidence: 99%

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Ivanova

Газизуллина

2020

Molecules

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The creation and analysis of a large variety of existing methods for the evaluation of integrated antioxidant properties are quite relevant in connection with a range of biological mechanisms of the antioxidants (AO) action. In this work, the existing methods are correlated with mechanisms of antioxidant action. It is shown that the results obtained by various methods are mainly incomparable. This can be connected with the implementation of various mechanisms of antioxidant action in methods. The analysis of the literature data presented in this review indicates the difficulty of creating a universal method and the feasibility of using integrated approaches based on the use of several methods that implement and combine various mechanisms of the chemical conversion of antioxidants. This review describes methods for studying the chelating ability of antioxidants, except for methods based on electron and hydrogen atom transfer reactions, which are currently not widely covered in modern literature. With the description of each mechanism, special attention is paid to electrochemical methods, as the interaction of active oxygen metabolites of radical and non-radical nature with antioxidants has an electron/proton/donor-acceptor nature, which corresponds to the nature of electrochemical methods and suggests that they can be used to study the interaction.

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“…Glutathione is determined by voltammetry and coulometric titration with electrogenerated oxidants using the bioamperometric end-point indication [29]. Possible schemes of the interaction of glutathione with electrogenerated halogens were discussed.…”

Section: Determination Of Low-molecular Bioantioxidantsmentioning

confidence: 99%

Antioxidants As Analytes in Analytical Chemistry

Будников

Ziyatdinova

2005

J Anal Chem

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Procedures for the determination of individual antioxidants of different nature in biological materials with the use of electrochemical, chromatographic, spectrochemical, and other methods were considered. The main performance characteristics of these procedures are presented. JOURNAL OF ANALYTICAL CHEMISTRY Vol. 60 No. 7 2005 ANTIOXIDANTS AS ANALYTES IN ANALYTICAL CHEMISTRY 601rings, the ortho and para positions of hydroxyl groups, their tert -butyl screening, the formation of semiquinone forms, thiol-containing compounds, the chelation of variable-valence metals, receptor interactions with the cell membrane, etc.

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Electrochemical Determination of Glutathione

Cited by 12 publications

References 4 publications

Analytical Capabilities of Coulometric Sensor Systems in the Antioxidants Analysis

Analytical Capabilities of Coulometric Sensor Systems in the Antioxidants Analysis

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Antioxidants As Analytes in Analytical Chemistry

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