Electrochemical immunosensor for detection of CA 15-3 biomarker in point-of-care

Rebelo, Tânia S.C.R.; Ribeiro, Danilo Monteiro; Sales, M. Goreti F.; Pereira, Carlos M.

doi:10.1016/j.sbsr.2021.100445

Cited by 22 publications

(14 citation statements)

References 38 publications

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“…This chip, including gold screen-printed electrodes, was utilized to create a portable device for keeping an eye on the oncomarker in a POCT for a medical setting. Low detection levels (LOD: 0.95 U/mL) and a broad linear concentration range (1.0 to 1000 U/mL) were both accomplished by the sophisticated biosensor [ 75 ]. Martin and his colleagues created a sandwich-type EI with a low LOD of 0.08 fg/mL.…”

Section: Electrochemical Biosensors Based On Nanostructured Materials...mentioning

confidence: 99%

A Comprehensive Review on Electrochemical Nano Biosensors for Precise Detection of Blood-Based Oncomarkers in Breast Cancer

Sadeghi

Naghib

et al. 2023

Biosensors

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Breast cancer (BC), one of the most common and life-threatening cancers, has the highest incidence rate among women. Early diagnosis of BC oncomarkers is considered the most effective strategy for detecting and treating BC. Finding the type and stage of BC in women as soon as possible is one of the greatest ways to stop its incidence and negative effects on medical treatment. The development of biosensors for early, sensitive, and selective detection of oncomarkers has recently attracted much attention. An electrochemical nano biosensor (EN) is a very suitable option for a powerful tool for cancer diagnosis. This comprehensive review provides information about the prevalence and pathobiology of BC, recent advances in clinically available BC oncomarkers, and the most common electrochemical nano biosensors for point-of-care (POC) detection of various BC oncomarkers using nanomaterial-based signal amplification techniques.

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Section: Electrochemical Biosensors Based On Nanostructured Materials...mentioning

confidence: 99%

A Comprehensive Review on Electrochemical Nano Biosensors for Precise Detection of Blood-Based Oncomarkers in Breast Cancer

Sadeghi

Naghib

et al. 2023

Biosensors

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“…Label-Free EC Immunosensors for Cancer Antigen 15-3 (CA 15-3) Detection CA 153 is a glycoprotein belonging to mucin 1 family. It is present in healthy human beings at a level lower than 30 U/mL and is a major serum oncomarker for breast cancer used for both detection and follow-up [76,77]. It is also used in cases of ovarian cancer [16,78] as it's level is heightened in about 70% of patients with epithelial ovarian cancer with most of the disease being in an advanced stage [78].…”

Section: Label-free Ec Immunosensors For P53 Detectionmentioning

confidence: 99%

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Ekwujuru

Olatunde

Klink

et al. 2023

Sensors

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Photoelectrochemical (PEC) sensing is an emerging technological innovation for monitoring small substances/molecules in biological or non–biological systems. In particular, there has been a surge of interest in developing PEC devices for determining molecules of clinical significance. This is especially the case for molecules that are markers for serious and deadly medical conditions. The increased interest in PEC sensors to monitor such biomarkers can be attributed to the many apparent advantages of the PEC system, including an enhanced measurable signal, high potential for miniaturization, rapid testing, and low cost, amongst others. The growing number of published research reports on the subject calls for a comprehensive review of the various findings. This article is a review of studies on electrochemical (EC) and PEC sensors for ovarian cancer biomarkers in the last seven years (2016–2022). EC sensors were included because PEC is an improved EC; and a comparison of both systems has, expectedly, been carried out in many studies. Specific attention was given to the different markers of ovarian cancer and the EC/PEC sensing platforms developed for their detection/quantification. Relevant articles were sourced from the following databases: Scopus, PubMed Central, Web of Science, Science Direct, Academic Search Complete, EBSCO, CORE, Directory of open Access Journals (DOAJ), Public Library of Science (PLOS), BioMed Central (BMC), Semantic Scholar, Research Gate, SciELO, Wiley Online Library, Elsevier and SpringerLink.

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“…The use of antibody-type biological components in the fabrication of electrochemical immunosensors represented the starting point for the development of this field ensuring promising perspectives for the biomedical domain. The presence of antibodies in the structure of electrochemical biosensors allowed the extraordinary improvement of the analytical performances in terms of selectivity for the target, this being mainly due to the specific antigen–antibody interaction [ 22 , 33 , 35 , 39 , 46 , 62 ].…”

Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

“…Thus, an innovative portable immunosensor based on a gold chip-type transducer functionalized with a self-assembled monolayer of mercaptosuccinic acid was designed for the detection of the CA 15–3. The covalent immobilization of the CA 15–3–specific antibodies via EDC/NHS chemistry with the carboxyl groups provided by the polymer ensured the selectivity of the immunosensor for the target protein in serum [ 33 ]. In another study, antibody immobilization is performed by interaction with the functions present on the composite film based on core/shell CdSe@ZnSQD, which also acts as an electroactive label, for the detection of HER2 in spiked serum [ 46 ].…”

Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

et al. 2022

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Recent years have shown that the diagnosis and monitoring of biomarkers involved in inflammatory-associated medical conditions such as cancer, neurological disorders, viral infections, or daily physical activities offer real benefits in increasing the quality of medical care and patient life quality. In this context, the use of integrated and portable platforms as point-of-care testing devices for biomedical analysis to enable early disease diagnosis and monitoring, which can be successfully used even at the patient’s bed, is an emergency nowadays. The development of low-cost, miniaturized, and portable, user-friendly devices that provide an answer in a timely manner, such as electrochemical sensors, is relevant for the elaboration of point-of-care testing devices. This review focuses on the recent progress in bioanalysis of both specific biomarkers and inflammatory-associated biomarkers present in several diseases like neoplasia, severe neurological disorders, viral infections, and usual physical activity and provides an overview of the state of the art over the most recent electrochemical (bio)sensors for the detection of inflammation-related biomarkers. Future perspectives of point-of-care testing to improve healthcare management are also discussed. Graphical abstract

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Electrochemical immunosensor for detection of CA 15-3 biomarker in point-of-care

Cited by 22 publications

References 38 publications

A Comprehensive Review on Electrochemical Nano Biosensors for Precise Detection of Blood-Based Oncomarkers in Breast Cancer

A Comprehensive Review on Electrochemical Nano Biosensors for Precise Detection of Blood-Based Oncomarkers in Breast Cancer

Electrochemical and Photoelectrochemical Immunosensors for the Detection of Ovarian Cancer Biomarkers

Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

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