Electrochemical Microbiosensor for Detecting COVID-19 in a Patient Sample Based on Gold Microcuboids Pattern

Abstract

As continues increasing the COVID-19 infections, there is an urgent need for developing fast, simple, selective, and accurate COVID-19 biosensors. A highly uniform gold (Au) microcuboid pattern was used as a microelectrode that allowed monitoring a small analyte. The electrochemical biosensor was used to monitor the COVID-19 S protein within a concentration range from 100 to 5 pmol L −1 ; it showed a lower detection limit of 276 fmol L −1 . Finally, the developed COVID-19 sensor was used to detect a positive sample from a human patient obtained through a nasal swab; the results were confirmed using the PCR technique. The results showed that the SWV technique showed high sensitivity towards detecting COVID-19 and good efficiency for detecting COVID-19 in a positive human sample.

Highly Efficient DNA Reporter for CRISPR/Cas12a-Based Specific and Sensitive Biosensor

“…The recent advent of SARS-CoV-2 and its variants have threatened humanity, incurring a high social cost and emphasized the importance of nucleic acid testing. Great research efforts have been devoted to detecting nucleic acids with high sensitivity and selectivity that could contribute to the effective control and prevention of viral transmission [1][2][3].…”

Analytical performances of different diagnostic methods for SARS-CoV-2 virus - A review

“…An electrochemical biosensor composed of a highly uniform gold microcuboid pattern to strengthen the conductivity was developed by Ref. [ 68 ]. In this work, the author used anti-COVID antibodies as a probe for the identification of COVID-19 characterized with cyclic voltammetry and square wave voltammetry techniques.…”

Nanomaterials and Biosensing Technology for the SARS-CoV-2 Detection

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