Electrochemical Palladium‐Catalyzed CH Functionalization

Abstract

Palladium‐catalyzed site‐selective functionalization of inert CH bonds has emerged as a versatile and transformative synthetic approach in modern organic synthesis, enabling tremendous possibility in the application of drug design, natural products synthesis, and material sciences. Despite significant progress, until recently, the oxidative functionalization of CH bonds predominantly relied on the use of stoichiometric amounts of sacrificial chemical oxidants that lead to the generation of undesired waste, thus compromising the environmental merits deriving from the CH activation chemistry. The recently developed electrooxidative CH functionalization via catalyst control strategy using transition‐metals as redox catalysts and electricity as an environmentally benign oxidant, offers a promising alternative to minimizes waste production, thereby providing a more sustainable and efficient pathway toward the catalytic conversion of CH bonds. In this article, we focus specifically on the progressive discoveries of electrochemical CH bond functionalizations catalyzed by palladium‐based catalysts, highlighting the enormous potential of this exciting field of synthetic chemistry, capable of offering increasingly efficient and sustainable routes for organic syntheses. These pallada‐electrocatalyzed CH bond transformations are presented in terms of CC and C–heteroatom bonds formation.