Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products

Solvothermally synthesized cobalt sulphide/reduced graphene oxide (CoS/rGO) was used to fabricate an electrochemical sensor for detection of artemisinin. Microscopic techniques were used to characterize CoS/rGO nanocomposite. The electrochemical sensor was fabricated by modifying the surface of glassy carbon electrode with CoS/rGO nanocomposite. [Fe(CN)6]3−/4− was used as a mediator to aid oxidation of artemisinin. Differential pulse voltammetric technique was used for the detection of artemisinin. A linear range of 30–100 μM was used. Experimentally, a detection limit of 0.5 μM was obtained. Therefore, the developed sensor can be used for quality control of artemisinin.

show abstract

“…R 1 2 was greater than R 2 . Based on this, the mechanism of detection of artemisinin can be said to be a diffusion‐controlled mechanism [16].…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Most of these analytical techniques or assays for artemisinin ( 1 ) reported until the end of year 2016 have been well documented and appraised in the book published by Tu . However, since then, several modified, and somewhat more precise and fast analytical protocols (Table ), mainly involving various HPLC systems, have been reported in the literature. The following subsections will summarise and appraise those new published protocols.…”

Section: Discussionmentioning

confidence: 99%

“…After the set potential is reached in this experiment, the working electrode's potential is ramped in the opposite direction to return to the initial potential. A combination of cyclic voltammetry and amperometry was applied for the determination of electrolytic products of artemisinin ( 1 ) . Although this was not exactly the method for quantitative or qualitative analysis of artemisinin ( 1 ), it was a method for analysing artemisinin derivatives.…”

Section: Discussionmentioning

confidence: 99%

“…28 Cyclic voltametric analysis A combination of cyclic voltammetry and amperometry for the determination of electrolytic products of artemisinin (1). 29 Fluorometric analysis A fluorometric analytical method for artemisinin (1) using microperoxidase-11 as a peroxidase biomimetic. 30 For the determination of artemisinin (1) in tablets and dried leaf samples of Artemisia annua.…”

Section: Assays/analytical Methods Brief Detailsmentioning

confidence: 99%

“…A combination of cyclic voltammetry and amperometry was applied for the determination of electrolytic products of artemisinin (1). 29 Although this was not exactly the method for quantitative or qualitative analysis of artemisinin (1), it was a method for analysing artemisinin derivatives.…”

Section: Cyclic Voltametric Analysismentioning

confidence: 99%

See 2 more Smart Citations

A review on the latest advances in extraction and analysis of artemisinin

Nahar

Chen

Sarker

2019

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Artemisinin (1), a well‐known natural antimalarial drug, is a sesquiterpene lactone that contains a unique peroxide bridge. Since its discovery, the amount of research into the analysis of artemisinin has increased considerably, and it has been further intensified since the Noble Prize win by Tu Youyou in the year 2015 for the discovery of artemisinin. Objective To review literature on the extraction and analysis of artemisinin, published during 2017–present, and to present an appraisal of those methods. Methodology Extensive literature search was carried out which involved, but not limited to, the use of, various databases, like Web of Knowledge, PubMed and Google Scholar, and relevant published materials including published books. The keywords used, in various combinations, with artemisinin being present in all combinations, in the search were artemisinin, Artemisia annua, analysis, extraction, quantitative, qualitative and quality control. Results During the period covered in this review, several methods of analysis of artemisinin have been reported, the most of which were liquid chromatography (LC)‐based methods. However, the use of new methods like near‐infrared analysis, fluorometirc analysis and molecular imprinting, and a significant increase in the use of computational tools have been observed. Mainly several methods involving supercritical fluid extraction and ultrasound‐assisted extraction of artemisinin have dominated the extraction area. Conclusions Newer analytical tools, as well as improved protocols for the known analytical tools, for qualitative and quantitative determination of artemisinin (1), have been made available by various researchers during the period covered by this review. Supercritical fluid extraction and ultrasound‐assisted extraction are still the methods of choice for extraction of artemisinin.

show abstract

Voltammetric methods for electrochemical characterization and quantification of artemether-based antimalarials

Hildebrand,

Merchant,

O'Hare

2024

Anal. Methods

View full text Add to dashboard Cite

show abstract

Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products

Cited by 3 publications

References 26 publications

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

A review on the latest advances in extraction and analysis of artemisinin

Voltammetric methods for electrochemical characterization and quantification of artemether-based antimalarials

Contact Info

Product

Resources

About