Electrochemical Sensing of Acyclovir at a Gold Electrode Modified with 2-Mercaptobenzothiazole–[5,10,15,20-tetrakis-(3-methoxy-4-hydroxyphenyl)porphyrinato]copper(II)

Joseph, Renjini; Kumar, Krishnapillai Girish

doi:10.2116/analsci.27.67

Cited by 32 publications

(8 citation statements)

References 27 publications

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“…ACV, the active form of VCV gave an oxidation peak at exactly the same potential (1.14 V). ACV shows the same oxidation mechanism as VCV as it has the same guanine moiety When the concentration of the interferents was 10 times that of the analyte, there was no significant change in the current response, i. e., the change in current response was less than 5 %, with the exception of caffeine, where the change in current response was 6.97 % and tryptophan where a complete change in the current response was observed (100 %) indicating that tryptophan interferes with the determination of VCV. When the concentration of the interfering substance was 100 times that of VCV, caffeine caused a 16.25 % change in the current response and famciclovir a structural analogue to VCV caused a 100 % change in the current response.…”

Section: Resultsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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A molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4 M with a limit of detection at 4.45x10−7 M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.

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Section: Resultsmentioning

confidence: 99%

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

et al. 2017

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“…The comprehensive performance of the sensor can be further improved by amplifying the electrochemical signal and specifying the interaction between the functional material and the target molecule. ACV, with electrochemical activity, can produce a redox reaction whose mechanism on the electrode is validated by several studies [80,85,86], under the action of a certain electric field. Therefore, the quantitative relationship between analyte concentration and physical parameters can be established to detect ACV.…”

Section: Electrochemical Analysis Technologymentioning

confidence: 88%

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Wei

Yao

et al. 2021

Molecules

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Acyclovir (ACV) is an effective and selective antiviral drug, and the study of its toxicology and the use of appropriate detection techniques to control its toxicity at safe levels are extremely important for medicine efforts and human health. This review discusses the mechanism driving ACV’s ability to inhibit viral coding, starting from its development and pharmacology. A comprehensive summary of the existing preparation methods and synthetic materials, such as 5-aminoimidazole-4-carboxamide, guanine and its derivatives, and other purine derivatives, is presented to elucidate the preparation of ACV in detail. In addition, it presents valuable analytical procedures for the toxicological studies of ACV, which are essential for human use and dosing. Analytical methods, including spectrophotometry, high performance liquid chromatography (HPLC), liquid chromatography/tandem mass spectrometry (LC-MS/MS), electrochemical sensors, molecularly imprinted polymers (MIPs), and flow injection–chemiluminescence (FI-CL) are also highlighted. A brief description of the characteristics of each of these methods is also presented. Finally, insight is provided for the development of ACV to drive further innovation of ACV in pharmaceutical applications. This review provides a comprehensive summary of the past life and future challenges of ACV.

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“…Figure S23. UV-Vis and HRMS of Cu(II) 5,10,15,20tetrakis-(4-carboxyphenyl)porphyrinate, Table S1: Data for Atom Economy calculation, Table S2: Data for E-factor calculation, Table S3: E-factor for the synthesis of Cu(II) complexes of TMePyP, Table S4: E-factor for the synthesis of Cu(II) complexes of 3-OHTPP, Table S5: Data for Ecoscale calculation [1,25,[30][31][32][33][34][35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Modern Methods for the Sustainable Synthesis of Metalloporphyrins

2021

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Metalloporphyrins are involved in many and diverse applications that require the preparation of these compounds in an efficient manner, which nowadays, also involves taking into consideration sustainability issues. In this context, we use ball milling mechanochemistry and sonochemistry for the rational development of synthetic strategies for the sustainable preparation of metalloporphyrins. Zinc, copper, cobalt and palladium complexes of hydrophobic porphyrins were obtained in high yields and under mechanical action with a moderate excess of the metal salt, without any solvent or additive. Sonochemistry prove to be a good alternative for the preparation of metal complexes of water-soluble porphyrins in good yields and short reaction times. Both strategies have good sustainability scores, close to the ideal values, which is useful in comparing and helping to choose the more adequate method.

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Electrochemical Sensing of Acyclovir at a Gold Electrode Modified with 2-Mercaptobenzothiazole–[5,10,15,20-tetrakis-(3-methoxy-4-hydroxyphenyl)porphyrinato]copper(II)

Cited by 32 publications

References 27 publications

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode

Critical Review of Synthesis, Toxicology and Detection of Acyclovir

Modern Methods for the Sustainable Synthesis of Metalloporphyrins

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