Electrochemical Sensing Platform Based on Graphene Oxide‐chitosan for Simultaneous Determination of some Antihypertensive Drugs

Abstract

The development of selective and simple methods for the determination of different analytes is of great interest. This is the first time to show the applicability of graphene oxide-chitosan (GO-CS) nanocomposite for designing an electrochemical nanosensor for determination of Amlodipine, Valsartan, and Hydrochlorothiazide, simultaneously. Differential pulse voltammet-rics current of AML, HCT, and VAL increased linearly in the ranges of 0.1-110, 0.1-110, and 1-230 μM with LOD of 5.5 × 10 À 2 , 3.5 × 10 À 2 and 8.6 × 10 À 2 μM, respectively. Finally, GO-CS/GCE was used for the detection of these drugs in commercial tablets and compared with the reference method (HPLC).