Electrochemical Sensing Platforms for HER2‐ECD Breast Cancer Biomarker Detection

Freitas, María; Nouws, Henri P. A.; Delerue–Matos, Cristina

doi:10.1002/elan.201800537

Cited by 54 publications

(18 citation statements)

References 21 publications

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“…Due to the direct signal being weak, Freitas et al [ 78 ] designed an LSV biosensor to detect the indirect signal. The screen-printed electrode was modified with multi-walled carbon nanotubes (MWCN), AuNPs, and HER2 antibodies, step by step.…”

Section: Biosensormentioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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Breast cancer has the highest cancer incidence rate in women. Early screening of breast cancer can effectively improve the treatment effect of patients. However, the main diagnostic techniques available for the detection of breast cancer require the corresponding equipment, professional practitioners, and expert analysis, and the detection cost is high. Tumor markers are a kind of active substance that can indicate the existence and growth of the tumor. The detection of tumor markers can effectively assist the diagnosis and treatment of breast cancer. The conventional detection methods of tumor markers have some shortcomings, such as insufficient sensitivity, expensive equipment, and complicated operations. Compared with these methods, biosensors have the advantages of high sensitivity, simple operation, low equipment cost, and can quantitatively detect all kinds of tumor markers. This review summarizes the biosensors (2013–2021) for the detection of breast cancer biomarkers. Firstly, the various reported tumor markers of breast cancer are introduced. Then, the development of biosensors designed for the sensitive, stable, and selective recognition of breast cancer biomarkers was systematically discussed, with special attention to the main clinical biomarkers, such as human epidermal growth factor receptor-2 (HER2) and estrogen receptor (ER). Finally, the opportunities and challenges of developing efficient biosensors in breast cancer diagnosis and treatment are discussed.

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Section: Biosensormentioning

confidence: 99%

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Hong

Sun

et al. 2022

Life

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“…Delerue-Matos et al studied screen-printed carbon electrodes (SPCEs)-MWCNTs/Au NPs and SPCE-Au NPs to improve the electrochemical analysis of the extracellular domain of the human epidermal growth factor receptor 2 (HER2-ECD) using linear sweep voltammetry [50]. In this analysis, the combination of MWCNT with Au NPs had the highest sensitivity.…”

Section: Biosensing Applications Of Cnt Compositesmentioning

confidence: 99%

Carbon Nanotubes, Graphene, and Carbon Dots as Electrochemical Biosensing Composites

Pandey

Chusuei

2021

Molecules

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Carbon nanomaterials (CNMs) have been extensively used as electrochemical sensing composites due to their interesting chemical, electronic, and mechanical properties giving rise to increased performance. Due to these materials’ unknown long-term ecological fate, care must be given to make their use tractable. In this review, the design and use of carbon nanotubes (CNTs), graphene, and carbon dots (CDs) as electrochemical sensing electrocatalysts applied to the working electrode surface are surveyed for various biosensing applications. Graphene and CDs are readily biodegradable as compared to CNTs. Design elements for CNTs that carry over to graphene and CDs include Coulombic attraction of components and using O or N atoms that serve as tethering points for attaching electrocatalytically active nanoparticles (NPs) and/or other additives.

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“…Due to the catalyst of Pt, CuO, and MWCNTs for the decomposition of H 2 O 2 , the Ab2 made multiple amplifications for signals [ 103 ]. Taking advantage of the better coverage of carbon nanomaterial (GNP included) and the larger accessible surface area for antibody immobilization, Freitas et al fabricated an electrochemical-based HER2 sensing platform on screen-printed carbon electrodes with Ab2-MWCNT/GNP for breast cancer detection [ 104 ]. Sardesai et al immobilized biomarkers onto the surface of CNTs which was modified with fluorescent labels and then used to detect IL-6 and PSA by measuring the ECL intensity [ 105 ].…”

Section: Electrochemical Biomarker Sensorsmentioning

confidence: 99%

Recent Progress of Biomarker Detection Sensors

Liu

Cui

2020

Research

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Early cancer diagnosis and treatment are crucial research fields of human health. One method that has proven efficient is biomarker detection which can provide real-time and accurate biological information for early diagnosis. This review presents several biomarker sensors based on electrochemistry, surface plasmon resonance (SPR), nanowires, other nanostructures, and, most recently, metamaterials which have also shown their mechanisms and prospects in application in recent years. Compared with previous reviews, electrochemistry-based biomarker sensors have been classified into three strategies according to their optimizing methods in this review. This makes it more convenient for researchers to find a specific fabrication method to improve the performance of their sensors. Besides that, as microfabrication technologies have improved and novel materials are explored, some novel biomarker sensors—such as nanowire-based and metamaterial-based biomarker sensors—have also been investigated and summarized in this review, which can exhibit ultrahigh resolution, sensitivity, and limit of detection (LoD) in a more complex detection environment. The purpose of this review is to understand the present by reviewing the past. Researchers can break through bottlenecks of existing biomarker sensors by reviewing previous works and finally meet the various complex detection needs for the early diagnosis of human cancer.

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Electrochemical Sensing Platforms for HER2‐ECD Breast Cancer Biomarker Detection

Cited by 54 publications

References 21 publications

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

A Review of Biosensors for Detecting Tumor Markers in Breast Cancer

Carbon Nanotubes, Graphene, and Carbon Dots as Electrochemical Biosensing Composites

Recent Progress of Biomarker Detection Sensors

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