Electrochemical sensors using screen-printed carbon electrode assemblies modified with the β-cyclodextrin or carboxymethylated β-cyclodextrin polymer films for determination of tricyclic antidepressive drugs

Ferancová, Adriana; Korgová, Elena; Buzinkaiová, Tatiana; Kutner, Włodzimierz; Stĕpánek, I; Labuda, Ján

doi:10.1016/s0003-2670(01)01308-3

Cited by 41 publications

(11 citation statements)

References 18 publications

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“…Moreover, the mediator mobility inside the polymer, required for its effective cross-reaction with the enzyme, is also relatively high [35] due to the open structure of the polymer [39]. Importantly, the use of carboxymethylated β-CD polymer (β-CDPA), which is a cation exchanger at pH values exceeding its pK a =4.6 [36], results in an enhancement of the retention of a cationic mediating couple, such as TTF + /TTF, or other substances (e.g., antidepressive cationic drug analytes [40,41]), due to the concurrent inclusion and cation exchange [34].…”

Section: Edyta Kosela · Hanna Elzanowska · Wlodzimierz Kutnermentioning

confidence: 99%

Charge mediation by ruthenium poly(pyridine) complexes in 'second-generation' glucose biosensors based on carboxymethylated β-cyclodextrin polymer membranes

2002

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Four different poly(pyridine) complexes of ruthenium, viz. Ru(II)(trpy)(phen)(OH(2))](2+) (1), trans-[Ru(III)(2,2'bpy)(2)(OH(2))(OH)](2+) (2), [(2,2'bpy)(2)(OH)Ru(III)ORu(III)(OH)(2,2'bpy)(2)](4+) (3), and [Ru(II)(4,4'bpy)(NH(3))(5)](2+) (4) (2,2'bpy=2,2'-bipyridine, 4,4'bpy=4,4'-bipyridine, trpy=2,2',2"-terpyridine, phen=1,10-phenanthroline), were tested as non-physiological charge mediators of 'second-generation' glucose biosensors. The membranes for these biosensors were prepared by casting anionic carboxymethylated beta-cyclodextrin polymer films (beta-CDPA) directly onto the Pt or glassy carbon (GC) disk electrodes. Simultaneously, glucose oxidase (GOD) was immobilized in the films by covalent bonding and the Ru complexes were incorporated both by inclusion in the beta-CD molecular cavities and by ion exchange at the fixed carboxymethyl cation-exchange sites. The leakage of the mediator from the polymer has been minimized by adopting a suitable pre-treatment procedure. The biosensors catalytic activities increased in the order 1<2<3<4, as established by linear sweep voltammetry. In case of complexes 2-4, the enzymatic glucose oxidation was mediated by the Ru complexes at their redox potentials. However, this oxidation was mediated by oxygen in case of complex 1 where H(2)O(2) was detected as the reaction product. The effectiveness of the mediators used in the presence of oxygen has been estimated using Pt and GC supports. The redox potential of the mediator does not depend on the support used, while the oxidation of H(2)O(2) proceeds on GC at much higher positive potentials than on Pt. The sensitivity and the linear concentration range of the biosensor studied varied significantly. For complex 4, which forms stable inclusion complex with beta-CD, the biosensor sensitivity was the highest and equal to 7.2 micro A mM(-1) cm(-2), detectability was as low as 1 mM, but the linear concentration range was limited only to 4 mM. In contrast, for complexes 2 and 3 the sensitivity was 0.4 and 3.2 micro A mM(-1) cm(-2), while the linear concentration range extended up to at least 24 and 14 mM glucose, respectively. Even though some common interfering substances, such as ascorbate, paracetamol or urea, are oxidized at potentials close to those of the Ru complex redox couples, their electro-oxidation currents at physiological concentrations are insignificant compared to those due to the biocatalytic oxidation of glucose. The biosensor response to glucose is reversible as demonstrated by the inhibition of GOD activity by Cu(II). That is, the Cu(II) concentration required to inhibit by half the response to glucose of the biosensor containing complex 2 was 1.0 mM. This inhibitory effect was fully reversed by addition of citrate, a ligand forming sufficiently stable complex with Cu(II).

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Section: Edyta Kosela · Hanna Elzanowska · Wlodzimierz Kutnermentioning

confidence: 99%

Charge mediation by ruthenium poly(pyridine) complexes in 'second-generation' glucose biosensors based on carboxymethylated β-cyclodextrin polymer membranes

2002

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“…The film can also be used for a pre-concentration step. β-cyclodextrin (β-CDP) or carboxymethylated β-cyclodextrin (β-CDPA) polymer films were used for determination of tricyclic antidepressive drugs such as azepines and phenothiazines [57]. The sensors were fabricated by casting a carbon-based SPE with thin films of β-CDP or β-CDPA.…”

Section: Membrane/filmmentioning

confidence: 99%

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Özkan

Kauffmann

Zuman

2015

Monographs in Electrochemistry

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“…Screen-printed carbon-based electrodes modified with thin films of the condensation polymers of -cyclodextrin ( -CDP) or carboxymethylated -cyclodextrin ( -CDPA) were used as electrochemical sensors for determination of tricyclic antidepressive drugs [108]. The azepine and phenothiazine antidepressive drugs were determined by using a simple twostep procedure developed which comprised a preconcentration step followed by the differential pulse voltammetry quantification.…”

Section: Applications Of Cyclodextrin Modified Electrode In Pharmaceumentioning

confidence: 99%

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Radi¹

2010

TOCBMJ

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Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal electrodes and nanoparticles, and cyclodextrin-modified multiwalled carbon nanotubes are also discussed.

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Electrochemical sensors using screen-printed carbon electrode assemblies modified with the β-cyclodextrin or carboxymethylated β-cyclodextrin polymer films for determination of tricyclic antidepressive drugs

Cited by 41 publications

References 18 publications

Charge mediation by ruthenium poly(pyridine) complexes in 'second-generation' glucose biosensors based on carboxymethylated β-cyclodextrin polymer membranes

Charge mediation by ruthenium poly(pyridine) complexes in 'second-generation' glucose biosensors based on carboxymethylated β-cyclodextrin polymer membranes

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

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