Electrochemical Synthesis and Antimicrobial Evaluation of some N-Phenyl α-Amino Acids

Abstract

In the present report, authors described a new synthetic route for the generation of N-phenyl amino acid derivatives using CO2 by C-C coupling reaction in an undivided cell containing a combination of Mg-Pt electrodes. The reactions were completed in a short time without the formation of any other side product. The final products were purified by a simple recrystallization procedure. The structures of newly prepared compounds were established by advanced spectroscopic techniques like 1H, 13C NMR, IR, & ESI-MS. All the prepared derivatives have shown well to excellent resistance tested bacterial and fungal strains. Interestingly, it was observed that the presence of polar groups (capable of forming H-bonds) like -OH (4d) and -NO2 (4e) at the para position of the phenyl ring show activity equivalent to the standard drugs.