Electrochemically Activated Conductive Ni-Based MOFs for Non-enzymatic Sensors Toward Long-Term Glucose Monitoring

Abstract

Continuous intensive monitoring of glucose is one of the most important approaches in recovering the quality of life of diabetic patients. One challenge for electrochemical enzymatic glucose sensors is their short lifespan for continuous glucose monitoring. Therefore, it is of great significance to develop non-enzymatic glucose sensors as an alternative approach for long-term glucose monitoring. This study presented a highly sensitive and selective electrochemical non-enzymatic glucose sensor using the electrochemically activated conductive Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 MOFs as sensing materials. The morphology and structure of the MOFs were investigated by scanning SEM and FTIR, respectively. The performance of the activated electrode toward the electrooxidation of glucose in alkaline solution was evaluated with cyclic voltammetry technology in the potential range from 0.2 V to 0.6 V. The electrochemical activated Ni-MOFs exhibited obvious anodic (0.46 V) and cathodic peaks (0.37 V) in the 0.1 M NaOH solution due to the Ni(II)/Ni(III) transfer. A linear relationship between the glucose concentrations (ranging from 0 to 10 mM) and anodic peak currents with R2 = 0.954 was obtained. It was found that the diffusion of glucose was the limiting step in the electrochemical reaction. The sensor exhibited good selectivity toward glucose in the presence of 10-folds uric acid and ascorbic acid. Moreover, this sensor showed good long-term stability for continuous glucose monitoring. The good selectivity, stability, and rapid response of this sensor suggests that it could have potential applications in long-term non-enzymatic blood glucose monitoring.

Recent advancements of metal–organic frameworks in sensing platforms: relevance in the welfare of the environment and the medical sciences with regard to cancer and SARS-CoV-2

“…Similarly, a Ni 3 (2,3,6,7,10,11-hexaiminotriphenylene) 2 MOF was prepared by Chen et al in 2020, which also works as an electrochemical sensor of glucose. 45 In this work, firstly the electrochemical response of the Ni-MOF electrode was investigated before and after activation by 0.1 M KOH. Results showed the appearance of two peaks due to the conversion of Ni( ii )/Ni( iii ) to each other (Fig.…”

Recent Advances in Materials for Enzyme-free Electrochemical Glucose Sensors

“…Among them, MOFs have drawn much attention and have been widely used to construct glucose sensors in recent years, as the easily tunable metal ions and organic linkers enable them to produce multifunctional nanocomposites. (13) MOFs, such as Ni-MOF, (30,110,111) Cu-MOF, (41) Co-MOF, (112)(113)(114)(115) and Ni-Co MOF, (58,116,117) and their derived composites, have all demonstrated outstanding performance for enzyme-free glucose detection.…”

Trends on the Development of Non-Enzymatic Electrochemical Sensors Modified with Metal-Organic Frameworks for the Quantification of Glucose

“…Chen et al, 90 mixed the linker 2,3,6,7,10,11-hexaiminotriphenylene (HITP) and the metal precursor NiCl 2 •6H 2 O to synthesize Ni 3 (HITP) 2 . Later, Ni 3 (HITP) 2 was used for surface modification of the GCE, quantifying glucose in alkaline medium.…”