Electrochemically deposited chitosan/Ag complex coatings on biomedical NiTi alloy for antibacterial application

Li, Penghui; Zhang, Xuming; Ren-ping, XU; Wang, Wenhao; Liu, Xiangmei; Yeung, Kelvin Wai Kwok; Chu, Paul K.

doi:10.1016/j.surfcoat.2013.05.037

Cited by 51 publications

(31 citation statements)

References 38 publications

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“…Above all, such CS-metal ion complexes are reported to have superior in vitro antibacterial activities as compared to free CS or antimicrobial metal salts [15,16]. Another key advantage of chelation is the ability to release the metal ions from the polymer matrix in a controlled manner [17,18]. Moreover, when choosing the appropriate therapeutic metal ions (TMIs), the chelated complex could assist vital biological processes that include osteogenesis and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Akhtar

Ilyas

Dlouhý

et al. 2020

IJMS

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Bacterial infection associated with medical implants is a major threat to healthcare. This work reports the fabrication of Copper(II)–Chitosan (Cu(II)–CS) complex coatings deposited by electrophoretic deposition (EPD) as potential antibacterial candidate to combat microorganisms to reduce implant related infections. The successful deposition of Cu(II)–CS complex coatings on stainless steel was confirmed by physicochemical characterizations. Morphological and elemental analyses by scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) spectroscopy verified the uniform distribution of copper in the Chitosan (CS) matrix. Moreover, homogeneous coatings without precipitation of metallic copper were confirmed by X-ray diffraction (XRD) spectroscopy and SEM micrographs. Controlled swelling behavior depicted the chelation of copper with polysaccharide chains that is key to the stability of Cu(II)–CS coatings. All investigated systems exhibited stable degradation rate in phosphate buffered saline (PBS)–lysozyme solution within seven days of incubation. The coatings presented higher mechanical properties with the increase in Cu(II) concentration. The crack-free coatings showed mildly hydrophobic behavior. Antibacterial assays were performed using both Gram-positive and Gram-negative bacteria. Outstanding antibacterial properties of the coatings were confirmed. After 24 h of incubation, cell studies of coatings confirms that up to a certain threshold concentration of Cu(II) were not cytotoxic to human osteoblast-like cells. Overall, our results show that uniform and homogeneous Cu(II)–CS coatings with good antibacterial and enhanced mechanical stability could be successfully deposited by EPD. Such antibiotic-free antibacterial coatings are potential candidates for biomedical implants.

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Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Akhtar

Ilyas

Dlouhý

et al. 2020

IJMS

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“…The compactness and thickness of the passive oxide layer determines the stability of NiTi alloy. To enhance the stability of the oxide layer and to improve the corrosion resistance various researchers have attempted to modify the surface of NiTi alloy using several techniques wherein the modified surface acts as an effective barrier for nickel release [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effect of anodization and annealing on corrosion and biocompatibility of NiTi alloy

Chembath

Balaraju

Sujata

2016

Surface and Coatings Technology

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“…One is surface modification1819 and the other is adding alloying elements in order to form novel TiNi-based alloy systems1620. For the surface modification strategy, Ag has been reported to implanted into TiNi biomedical alloy surfaces to provide antibacterial properties182122, besides, Graphene oxide based coatings have been applied into TiNi alloy surface for antibacterial purposes23. In addition, nanoparticles (AuNPs) and a natural polymer as Chitosan (CS) have been introduced into TiNi alloy surface for improvement of antibacterial effect of TiNi alloy24.…”

Section: Discussionmentioning

confidence: 99%

Design and development of novel antibacterial Ti-Ni-Cu shape memory alloys for biomedical application

Qiu

Zhou

et al. 2016

Sci Rep

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In the case of medical implants, foreign materials are preferential sites for bacterial adhesion and microbial contamination, which can lead to the development of prosthetic infections. Commercially biomedical TiNi shape memory alloys are the most commonly used materials for permanent implants in contact with bone and dental, and the prevention of infections of TiNi biomedical shape memory alloys in clinical cases is therefore a crucial challenge for orthopaedic and dental surgeons. In the present study, copper has been chosen as the alloying element for design and development novel ternary biomedical Ti‒Ni‒Cu shape memory alloys with antibacterial properties. The effects of copper alloying element on the microstructure, mechanical properties, corrosion behaviors, cytocompatibility and antibacterial properties of biomedical Ti‒Ni‒Cu shape memory alloys have been systematically investigated. The results demonstrated that Ti‒Ni‒Cu alloys have good mechanical properties, and remain the excellent shape memory effects after adding copper alloying element. The corrosion behaviors of Ti‒Ni‒Cu alloys are better than the commercial biomedical Ti‒50.8Ni alloys. The Ti‒Ni‒Cu alloys exhibit excellent antibacterial properties while maintaining the good cytocompatibility, which would further guarantee the potential application of Ti‒Ni‒Cu alloys as future biomedical implants and devices without inducing bacterial infections.

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Electrochemically deposited chitosan/Ag complex coatings on biomedical NiTi alloy for antibacterial application

Cited by 51 publications

References 38 publications

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Effect of anodization and annealing on corrosion and biocompatibility of NiTi alloy

Design and development of novel antibacterial Ti-Ni-Cu shape memory alloys for biomedical application

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