Electrochromic polyoxometalate material as a sensor of bacterial activity

Abstract

Lactobacillus fermentum, a bacterium of human microbiota, acts as an electron donor for the electrochromic [P2Mo(VI)18O62](6-). Since the reductive capacity of L. fermentum correlates with its metabolic activity, the reaction with [P2Mo(VI)18O62](6-) affords a means of evaluating its activity. Following this logic, we have concluded that vancomycin severely affects the activity of L. fermentum whereas omeprazole does not.

Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line

“…Polyoxometalates (POMs) are a large family of metal oxide cluster anions with different applications in magnetics 1 2 3 4 , material 5 6 7 8 9 , catalysis 10 11 12 13 , and medicine 14 15 16 17 18 19 20 21 22 23 24 25 . Among them, the medicinal chemistry of POM is of great interest because various POMs can exhibit effective anticancer 15 16 17 , antiviral 18 19 and antibacterial 20 21 22 performances by inducting cell apoptosis and inhibiting ATP generation 15 . Recently, many research works have revealed that a variety of POMs are capable of penetrating across the blood brain barrier (BBB) 23 24 25 , endowing POMs with opportunity to be available agents for brain diseases.…”

“…In the medicinal chemistry of POMs, previous works on cancer therapy were mainly focused on the heteropolyacids, including Keggin 14 19 20 21 and Wells-Dawson 23 24 25 . However, these POMs are stable in vivo and cannot be timely excreted, causing the side effect.…”

Skin color-specific and spectrally-selective naked-eye dosimetry of UVA, B and C radiations

“…A particularly exciting property of POMs is their ability to undergo a multi-step reduction in the presence of an electron (e − ) donor and UV light, leading to a family of mixed-valence species 46 . The reduced POMs, commonly known as “heteropoly blues”, show a characteristic deep blue color, thereby providing them with photoelectrochromic properties 47 , 48 . However, to be able to use POMs to spectrally differentiate among different UVRs, a critical step is to select an appropriate e − donor that is able to reduce PMA molecules to different redox states under different UVRs, particularly in an ambient oxygen-rich environment.…”

AuNPs@PMo12nanozyme: highly oxidase mimetic activity for sensitive and specific colorimetric detection of acetaminophen

“…Polyoxometalates (POMs) have received great interest owing to their wide range of applications in biochemistry, catalyst, 14 and sensing. 15 POMs can be used as reducing and stabilizing agents in aqueous solutions in ambient conditions. 16,17 Also, POMs can be used as a multi-electron reducing agent which is useful for the preparation of noble metal nanoparticles.…”